High-resolution mass spectrometry for human exposomics: Expanding chemical space coverage

Y Lai, JP Koelmel, DI Walker, EJ Price… - Environmental …, 2024 - ACS Publications
In the modern “omics” era, measurement of the human exposome is a critical missing link
between genetic drivers and disease outcomes. High-resolution mass spectrometry …

[HTML][HTML] Integrating-omics approaches into population-based studies of endocrine disrupting chemicals: A scoping review

L Maitre, P Jedynak, M Gallego, L Ciaran… - Environmental …, 2023 - Elsevier
Health effects of endocrine disrupting chemicals (EDCs) are challenging to detect in the
general population. Omics technologies become increasingly common to identify early …

[HTML][HTML] Integrating the social environment with an equity perspective into the exposome paradigm: a new conceptual framework of the Social Exposome

H Gudi-Mindermann, M White, J Roczen, N Riedel… - Environmental …, 2023 - Elsevier
The importance of the social environment and social inequalities in disease etiology is well-
known due to the profound research and conceptual framework on social determinants of …

[HTML][HTML] Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)

N Pálešová, L Maitre, N Stratakis, K Řiháčková… - International Journal of …, 2023 - Elsevier
Introduction Firefighting is one of the most hazardous occupations due to exposure to per-
and polyfluoroalkyl substances (PFAS) and polycyclic aromatic hydrocarbons (PAHs). Such …

Machine learning in causal inference for epidemiology

C Moccia, G Moirano, M Popovic, C Pizzi… - European Journal of …, 2024 - Springer
In causal inference, parametric models are usually employed to address causal questions
estimating the effect of interest. However, parametric models rely on the correct model …

[HTML][HTML] The exposome approach to study children's health

E Handakas, O Robinson, JE Laine - Current Opinion in Environmental …, 2023 - Elsevier
The exposome represents an interdisciplinary science and promising field of research that
can identify how multiple facets of the environment influences health across the lifespan. A …

Applications of mixture methods in epidemiological studies investigating the health impact of persistent organic pollutants exposures: a scoping review

S Pan, Z Li, B Rubbo, V Quon-Chow, JC Chen… - Journal of Exposure …, 2024 - nature.com
Abstract Background Persistent organic pollutants (POPs) are environmental chemicals
characterized by long half-lives in nature and human bodies, posing significant health risks …

[HTML][HTML] Exploring the Exposome Spectrum: Unveiling Endogenous and Exogenous Factors in Non-Communicable Chronic Diseases

L Di Renzo, P Gualtieri, G Frank, R Cianci, M Caldarelli… - Diseases, 2024 - mdpi.com
The exposome encompasses all endogenous and exogenous exposure individuals
encounter throughout their lives, including biological, chemical, physical, psychological …

Prenatal environmental exposures associated with sex differences in childhood obesity and neurodevelopment

A Cáceres, N Carreras-Gallo, S Andrusaityte… - BMC medicine, 2023 - Springer
Background Obesity and neurodevelopmental delay are complex traits that often co-occur
and differ between boys and girls. Prenatal exposures are believed to influence children's …

Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs)

MK Chung, JS House, FS Akhtari, KC Makris… - …, 2024 - academic.oup.com
This paper explores the exposome concept and its role in elucidating the interplay between
environmental exposures and human health. We introduce two key concepts critical for …