Neuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system and one of the
most common solid tumors in infancy. Amplification of MYCN, copy number alterations …

Despite advances in diagnostic tools and therapeutic options, treatment resistance remains
a challenge for many cancer patients. Recent studies have found evidence that autophagy …

Histone deacetylases (HDACs) inhibit the acetylation of crucial autophagy genes, thereby
deregulating autophagy and autophagic cell death (ACD) and facilitating cancer cell …

Neuroblastoma is one of the most common pediatric solid tumors that threaten the health of
children, accounting for about 15% of childhood cancer-related mortality in the United …

Thioredoxin‐related protein of 14 kDa (TRP14; also named TXNDC17 for thioredoxin
domain‐containing protein 17) is a highly conserved and ubiquitously expressed …

Autophagy is a highly regulated multi-step process that occurs at the basal level in almost all
cells. Although the deregulation of the autophagy process has been described in several …

High-risk neuroblastoma (NB) is sensitive to chemotherapy but susceptible to
chemoresistance. In this study, we aimed to analyze the incidence of chemoresistance in …

Beclin1, a key regulator of autophagy, has been demonstrated to be associated with cancer
cell resistance to chemotherapy. Paclitaxel is a conventional chemotherapeutic drug used in …

Objective: Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in
the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P …

High-risk neuroblastoma is an aggressive childhood cancer that is characterized by high
rates of chemoresistance and frequent metastatic relapse. A number of studies have …