Purpose Rectal suction biopsy (RSB) combined with acetylcholinesterase (AChE) staining is
currently the gold standard for the diagnosis of Hirschsprung's disease (HD). However …

Background Hirschsprung's disease (HD) is one of the most common congenital anomalies
of colorectal function, affecting approximately 1 in 5000 live births, with a 4: 1 male …

Diagnosis of Hirschsprung disease (HD) is quite entirely based on the histopathological
analysis of suction rectal biopsies. This hematoxylin and eosin approach has some …

Purpose Numerous studies have investigated the prevalence of constipation and fecal
incontinence (FI) in the general population and, even though these disorders are known to …

Historically, the diagnosis of Hirschsprung disease was made by evaluating multiple
hematoxylin and eosin–stained slides and performing acetylcholinesterase histochemical …

PURPOSE: Transanal endorectal pull-through (TEPT) has drastically changed the treatment
of Hirschsprung's disease (HD). A short follow-up of children submitted to TEPT reveals …

Objectives: Describe the different methods of histopathological confirmation of Hirschsprung
disease. Review the appropriate evaluation process for Hirschsprung disease. Outline the …

Hirschsprung disease is a congenital malformation resulting from the failure of neural crest
cells to migrate into the gastrointestinal tract. The exact cause of this disorder is unknown …

H irschsprung's disease (HSCR), a congenital gastrointestinal disorder, is one of the most
common causes of neonatal bowel obstruction. Without an early screening and diagnosis …

INTRODUCTION: Calretinin, a calcium-binding protein, has been reported to be an
important new marker in Hirschsprung's disease (HD). The aim is to study the diagnostic …