[HTML][HTML] Approaches for corneal endothelium regenerative medicine

P Catala, G Thuret, H Skottman, JS Mehta… - Progress in retinal and …, 2022 - Elsevier
The state of the art therapy for treating corneal endothelial disease is transplantation.
Advances in the reproducibility and accessibility of surgical techniques are increasing the …

The novel role of lymphatic vessels in the pathogenesis of ocular diseases

T Clahsen, K Hadrian, M Notara, SL Schlereth… - Progress in Retinal and …, 2023 - Elsevier
Historically, the eye has been considered as an organ free of lymphatic vessels. In recent
years, however, it became evident, that lymphatic vessels or lymphatic-like vessels …

Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation

V Singh, A Tiwari, AR Kethiri… - Stem cells translational …, 2021 - academic.oup.com
Limbal stem cells are involved in replenishing and maintaining the epithelium of the cornea.
Damage to the limbus due to chemical/physical injury, infections, or genetic disorders leads …

[HTML][HTML] Deep learning using preoperative AS-OCT predicts graft detachment in DMEK

A Patefield, Y Meng, M Airaldi, G Coco… - … Vision Science & …, 2023 - jov.arvojournals.org
Purpose: To evaluate a novel deep learning algorithm to distinguish between eyes that may
or may not have a graft detachment based on pre–Descemet membrane endothelial …

P-Cadherin Is Expressed by Epithelial Progenitor Cells and Melanocytes in the Human Corneal Limbus

N Polisetti, L Sharaf, G Martin, G Schlunck, T Reinhard - Cells, 2022 - mdpi.com
Interactions between limbal epithelial progenitor cells (LEPC) and surrounding niche cells,
which include limbal mesenchymal stromal cells (LMSC) and melanocytes (LM), are …

Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency

A Norrick, J Esterlechner, E Niebergall-Roth… - Stem Cell Research & …, 2021 - Springer
Background While therapeutic success of the limbal tissue or cell transplantation to treat
severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the …

Induced pluripotent stem cell-derived corneal cells: current status and application

N Mahmood, TC Suh, KM Ali, E Sefat… - Stem Cell Reviews and …, 2022 - Springer
Deficiency and dysfunction of corneal cells leads to the blindness observed in corneal
diseases such as limbal stem cell deficiency (LSCD) and bullous keratopathy. Regenerative …

Y-27632 and dual media culture approach promote the construction and transplantation of rabbit limbal epithelial cell sheets via cell spheroid culture and auto …

P Wang, S Shen, Y Guo, J Cao, D Zhu, M Xie, Q Yu… - Acta Biomaterialia, 2025 - Elsevier
The shortage of corneal donors and the limitations in tissue engineering grafts, such as
biocompatibility and mechanical properties, pose significant challenges in corneal …

Biomechanical modulation therapy—a stem cell therapy without stem cells for the treatment of severe ocular burns

RM Gouveia, CJ Connon - Translational Vision Science & …, 2020 - tvst.arvojournals.org
Ocular injuries caused by chemical and thermal burns are often unmanageable and
frequently result in disfigurement, corneal haze/opacification, and vision loss. Currently, a …

Scheimpflug backscatter imaging of the fibrillar layer in fuchs endothelial corneal dystrophy

A Hribek, M Mestanoglu, T Clahsen, N Reinking… - American Journal of …, 2022 - Elsevier
PURPOSE A central collagen-rich subendothelial fibrillar layer (FL) correlates with areas of
accentuated loss of corneal endothelial cells in advanced Fuchs endothelial corneal …