Alternative functions of CRISPR–Cas systems in the evolutionary arms race

P Mohanraju, C Saha, P van Baarlen… - Nature Reviews …, 2022 - nature.com
CRISPR–Cas systems of bacteria and archaea comprise chromosomal loci with typical
repetitive clusters and associated genes encoding a range of Cas proteins. Adaptation of …

The CRISPR-Cas mechanism for adaptive immunity and alternate bacterial functions fuels diverse biotechnologies

S Newsom, HP Parameshwaran, L Martin… - Frontiers in cellular and …, 2021 - frontiersin.org
Bacterial and archaeal CRISPR-Cas systems offer adaptive immune protection against
foreign mobile genetic elements (MGEs). This function is regulated by sequence specific …

Research on the drug resistance mechanism of foodborne pathogens

H Ge, Y Wang, X Zhao - Microbial Pathogenesis, 2022 - Elsevier
Foodborne diseases caused by foodborne pathogens are one of the main problems
threatening human health and safety. The emergence of multi-drug resistant strains due to …

A current review of pathogenicity determinants of Streptococcus sp.

PS Lannes‐Costa, JSS De Oliveira… - Journal of Applied …, 2021 - academic.oup.com
The genus Streptococcus comprises important pathogens, many of them are part of the
human or animal microbiota. Advances in molecular genetics, taxonomic approaches and …

Genomic characterization of skin and soft tissue Streptococcus pyogenes isolates from a low-income and a high-income setting

SY Bah, AJ Keeley, EP Armitage, H Khalid… - MSphere, 2023 - Am Soc Microbiol
Streptococcus pyogenes is a leading cause of human morbidity and mortality, especially in
resource-limited settings. The development of a vaccine against S. pyogenes is a global …

CRISPR-Cas system: the powerful modulator of accessory genomes in prokaryotes

A Butiuc-Keul, A Farkas, R Carpa, D Iordache - Microbial physiology, 2022 - karger.com
Being frequently exposed to foreign nucleic acids, bacteria and archaea have developed an
ingenious adaptive defense system, called CRISPR-Cas. The system is composed of the …

[HTML][HTML] Virulence-related transcriptional regulators of Streptococcus pyogenes

LA Vega, H Malke, KS McIver - Streptococcus pyogenes: Basic …, 2022 - ncbi.nlm.nih.gov
Control of virulence gene expression in S. pyogenes is under the charge of 13 two-
component regulatory systems and at least 30 transcriptional regulators known thus far …

CRISPR-Cas systems: role in cellular processes beyond adaptive immunity

V Devi, K Harjai, S Chhibber - Folia Microbiologica, 2022 - Springer
Clustered regularly interspaced short palindromic repeats and associated Cas proteins
(CRISPR-Cas) are the only known adaptive immune system in prokaryotes. CRISPR-Cas …

Analysis of genetic structure and function of clustered regularly interspaced short palindromic repeats loci in 110 Enterococcus strains

S Tao, D Zhou, H Chen, N Li, L Zheng, Y Fang… - Frontiers in …, 2023 - frontiersin.org
Clustered regularly interspaced short palindromic repeats (CRISPR) and their CRISPR-
associated proteins (Cas) are an adaptive immune system involved in specific defenses …

The intricate pathogenicity of group a Streptococcus: A comprehensive update

H Bergsten, V Nizet - Virulence, 2024 - Taylor & Francis
ABSTRACT Group A Streptococcus (GAS) is a versatile pathogen that targets human
lymphoid, decidual, skin, and soft tissues. Recent advancements have shed light on its …