Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-
inflammatory effects, drugs that neutralize TNF were developed and are clinically used to …

The cytokine TNF signals via two distinct receptors, TNF receptor 1 (TNFR1) and TNFR2,
and is a central mediator of various immune-mediated diseases. Indeed, TNF-neutralizing …

Aim Spinal cord injury (SCI) involves multiple pathological processes. Ferroptosis has been
shown to play a critical role in the injury process. We wanted to explore whether zinc can …

TNF is a key proinflammatory and immunoregulatory cytokine whose deregulation is
associated with the development of autoimmune diseases and other pathologies. Recent …

Regulatory T cells (Treg cells) restrict immune system activity, such as in response to self-
antigens, and are switched on by tumor necrosis factor receptor 2 (TNFR2). Therapeutic …

Background Tumour necrosis factor (TNF) is a pleiotropic cytokine and master regulator of
the immune system. It acts through two receptors resulting in often opposing biological …

Tumor necrosis factor (TNF) receptor-2 (TNFR2) has attracted considerable interest as a
target for immunotherapy. Indeed, using oligomeric fusion proteins of single chain-encoded …

T cells participate in the repair process and immune response in the CNS post‐traumatic
injury and play both a beneficial and harmful role. Together with nerve cells and other …

TNFR2 agonists have been investigated as potential therapies for inflammatory diseases
due to their ability to activate and expand immunosuppressive CD4+ Foxp3+ Treg cells and …

Simple Summary Blocking detrimental neuroinflammation and boosting a pro-regenerative
environment are promising new therapeutic approaches in spinal cord injury (SCI). Selective …