Copy number variants (CNVs) play an important role in human disease and population
diversity. Advancements in technology have allowed for the analysis of CNVs in thousands …

A small subset of human immunodeficiency virus type 1 (HIV-1)-infected, therapy-naive
individuals–referred to as long-term non-progressors (LTNPs)–maintain a favourable course …

Copy number variants affect both disease and normal phenotypic variation, but those lying
within heavily duplicated, highly identical sequence have been difficult to assay. By …

To extend the understanding of host genetic determinants of HIV-1 control, we performed a
genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study …

HIV elite controllers maintain a population of CD4+ T cells endowed with high avidity for Gag
antigens and potent effector functions. How these HIV-specific cells avoid infection and …

Hundreds of genes reside in structurally complex, poorly understood regions of the human
genome,,. One such region contains the three amylase genes (AMY2B, AMY2A and AMY1) …

Twenty-five years after the discovery of HIV as the cause of AIDS there is still no effective
vaccine and no cure for this disease. HIV susceptibility shows a substantial degree of …

The chemokine receptor CCR5 has been the focus of intensive studies since its role as a
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …

Over the past decade, the ubiquity of copy number variants (CNVs, the gain or loss of
genomic material) in the genomes of healthy humans has become apparent. Although some …

Background Various patterns of HIV-1 disease progression are described in clinical practice
and in research. There is a need to assess the specificity of commonly used definitions of …