Prefrontal cortex, amygdala, and threat processing: implications for PTSD
Posttraumatic stress disorder can be viewed as a disorder of fear dysregulation. An
abundance of research suggests that the prefrontal cortex is central to fear processing—that …
abundance of research suggests that the prefrontal cortex is central to fear processing—that …
Laboratory models of post-traumatic stress disorder: The elusive bridge to translation
Post-traumatic stress disorder (PTSD) is a debilitating mental illness composed of a
heterogeneous collection of symptom clusters. The unique nature of PTSD as arising from a …
heterogeneous collection of symptom clusters. The unique nature of PTSD as arising from a …
Anxious individuals shift emotion control from lateral frontal pole to dorsolateral prefrontal cortex
Anxious individuals consistently fail in controlling emotional behavior, leading to excessive
avoidance, a trait that prevents learning through exposure. Although the origin of this failure …
avoidance, a trait that prevents learning through exposure. Although the origin of this failure …
Functional neuroanatomy of emotion and its regulation in PTSD
JM Fitzgerald, JA DiGangi, KL Phan - Harvard review of psychiatry, 2018 - journals.lww.com
Posttraumatic stress disorder (PTSD) is a devastating disorder, linked to profound mental,
physical, occupational, and functional impairment. In addition, it is a highly complex …
physical, occupational, and functional impairment. In addition, it is a highly complex …
Global connectivity and local excitability changes underlie antidepressant effects of repetitive transcranial magnetic stimulation
Repetitive transcranial magnetic stimulation (rTMS) is a commonly-used treatment for major
depressive disorder (MDD). However, our understanding of the mechanism by which TMS …
depressive disorder (MDD). However, our understanding of the mechanism by which TMS …
PTSD psychotherapy outcome predicted by brain activation during emotional reactivity and regulation
GA Fonzo, MS Goodkind, DJ Oathes… - American Journal of …, 2017 - Am Psychiatric Assoc
Objective: Exposure therapy is an effective treatment for posttraumatic stress disorder
(PTSD), but many patients do not respond. Brain functions governing treatment outcome are …
(PTSD), but many patients do not respond. Brain functions governing treatment outcome are …
Resting fMRI-guided TMS results in subcortical and brain network modulation indexed by interleaved TMS/fMRI
DJ Oathes, JP Zimmerman, R Duprat, SS Japp… - Experimental brain …, 2021 - Springer
Traditional non-invasive imaging methods describe statistical associations of functional co-
activation over time. They cannot easily establish hierarchies in communication as done in …
activation over time. They cannot easily establish hierarchies in communication as done in …
Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: A randomized, placebo-controlled pilot trial
JC Flanagan, LM Sippel, A Wahlquist… - Journal of psychiatric …, 2018 - Elsevier
Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition for which Prolonged
Exposure (PE) therapy is highly efficacious. However, for some individuals, premature …
Exposure (PE) therapy is highly efficacious. However, for some individuals, premature …
Anterior prefrontal brain activity during emotion control predicts resilience to post-traumatic stress symptoms
Regulating social emotional actions is essential for coping with life stressors and is
associated with control by the anterior prefrontal cortex (aPFC) over the amygdala. However …
associated with control by the anterior prefrontal cortex (aPFC) over the amygdala. However …
A latent variable approach to differentiating neural mechanisms of irritability and anxiety in youth
Importance Comorbidity is ubiquitous in psychiatry, but it is unclear how to differentiate
neural mechanisms of co-occurring symptoms. Pediatric irritability and anxiety symptoms are …
neural mechanisms of co-occurring symptoms. Pediatric irritability and anxiety symptoms are …