The origin story and emergence of molecular biology is muddled. The early triumphs in bacterial genetics and the complexity of animal and plant genomes complicate an intricate …
C Kern, Y Wang, X Xu, Z Pan, M Halstead… - Nature …, 2021 - nature.com
Gene regulatory elements are central drivers of phenotypic variation and thus of critical importance towards understanding the genetics of complex traits. The Functional Annotation …
M Tsakiroglou, A Evans, M Pirmohamed - Frontiers in Genetics, 2023 - frontiersin.org
Diagnostics require precision and predictive ability to be clinically useful. Integration of multi- omic with clinical data is crucial to our understanding of disease pathogenesis and …
Y Li, M Tan, A Akkari-Henić, L Zhang, M Kip… - Nature Biomedical …, 2024 - nature.com
The functions of non-coding regulatory elements (NCREs), which constitute a major fraction of the human genome, have not been systematically studied. Here we report a method …
D Ha, D Kim, I Kim, Y Oh, JH Kong… - Nucleic Acids …, 2022 - academic.oup.com
Mouse models have been engineered to reveal the biological mechanisms of human diseases based on an assumption. The assumption is that orthologous genes underlie …
The last two decades have seen impressive advances in functional genomics, but we are still a long way from understanding the complexity of gene function. Here, we pose …
The accumulation of large epigenomics data consortiums provides us with the opportunity to extrapolate existing knowledge to new cell types and conditions. We propose Epitome, a …
M Vietri Rudan, KH Sipilä, C Philippeos, C Gânier… - bioRxiv, 2023 - biorxiv.org
A fundamental challenge in molecular biology is to understand how evolving genomes can acquire new functions. Several recent studies have underscored how non-conserved …
J Trendel, S Trendel, S Sha, B Kuster - bioRxiv, 2024 - biorxiv.org
In a human cell, DNA is packed in histones, RNA, and chromatin-associated proteins, forming a cohesive gel. At any given moment, only a specific subset of the proteome has …