Insulin and insulin resistance in Alzheimer's disease

A Sędzikowska, L Szablewski - International journal of molecular sciences, 2021 - mdpi.com
Insulin plays a range of roles as an anabolic hormone in peripheral tissues. It regulates
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …

Crosstalk between gut and brain in Alzheimer's disease: the role of gut microbiota modulation strategies

U Shabbir, MS Arshad, A Sameen, DH Oh - Nutrients, 2021 - mdpi.com
The gut microbiota (GM) represents a diverse and dynamic population of microorganisms
and about 100 trillion symbiotic microbial cells that dwell in the gastrointestinal tract. Studies …

Wound healing potential of insulin-loaded nanoemulsion with Aloe vera gel in diabetic rats

T Chakraborty, S Gupta, A Nair, S Chauhan… - Journal of Drug Delivery …, 2021 - Elsevier
Diabetes skin infection is a very common disorder in hyperglycemic patients. This study
evaluated the prospective of developing a topical gel formulation of Aloe vera with insulin …

Mechanisms of Antidiabetic Activity of Methanolic Extract of Punica granatum Leaves in Nicotinamide/Streptozotocin-Induced Type 2 Diabetes in Rats

S Pottathil, P Nain, MA Morsy, J Kaur, BE Al-Dhubiab… - Plants, 2020 - mdpi.com
The current study aimed to establish the mechanisms of antidiabetic activity of methanolic
extract of Punica granatum leaves (MEPGL) in nicotinamide/streptozotocin-induced type 2 …

Rational drug design strategies for the development of promising multi-target directed indole hybrids as Anti-Alzheimer agents

N George, MJ Akhtar, KA Al Balushi, SA Khan - Bioorganic Chemistry, 2022 - Elsevier
Alzheimer's disease (AD) is a neurological disorder that leads to dementia ie, progressive
memory loss accompanied with worsening of thinking ability of an individual. The cause of …

Association of Alzheimer's dementia with oral bacteria, vitamin B12, folate, homocysteine levels, and insulin resistance along with its pathophysiology, genetics …

P Prajjwal, S Asharaf, D Makhanasa, A Yamparala… - Disease-a-Month, 2023 - Elsevier
Alzheimer's disease is a prevalent form of dementia, particularly among the elderly
population. It is characterized by progressive cognitive decline and neurodegeneration …

[HTML][HTML] Design, synthesis and in vitro biological activities of coumarin linked 1, 3, 4-oxadiazole hybrids as potential multi-target directed anti-Alzheimer agents

N George, B Al Sabahi, M AbuKhader… - Journal of King Saud …, 2022 - Elsevier
Introduction Alzheimer's disease (AD) is one of the most common and prevalent forms of
neurodegenerative diseases. Coumarin is a versatile scaffold that exhibits a wide range of …

The interaction between insulin resistance and Alzheimer's disease: a review article

NY Albar, H Hassaballa, H Shikh, Y Albar… - Postgraduate …, 2024 - Taylor & Francis
Insulin serves multiple functions as a growth-promoting hormone in peripheral tissues. It
manages glucose metabolism by promoting glucose uptake into cells and curbing the …

An insight into the neuroprotective effects and molecular targets of pomegranate (Punica granatum) against Alzheimer's disease

N George, M AbuKhader, K Al Balushi… - Nutritional …, 2023 - Taylor & Francis
Alzheimer's disease (AD) is a progressive neurodegenerative disease that still has no
permanent cure. The drugs prescribed in the present days are only for symptomatic relief for …

Evaluation of serum neurofilament light chain and glial fibrillary acidic protein in the diagnosis of Alzheimer's disease

T Fang, Y Dai, X Hu, Y Xu, J Qiao - Frontiers in Neurology, 2024 - frontiersin.org
Purpose This study aimed to evaluate the use of serum neurofilament light chain (NfL) and
glial fibrillary acidic protein (GFAP) in the diagnosis of Alzheimer's disease (AD) and the …