Polymeric micelles in cancer therapy: State of the art

B Ghosh, S Biswas - Journal of Controlled Release, 2021 - Elsevier
In recent years, polymeric micelles have been extensively utilized in pre-clinical studies for
delivering poorly soluble chemotherapeutic agents in cancer. Polymeric micelles are formed …

Activation of PI3K/AKT/mTOR pathway causes drug resistance in breast cancer

C Dong, J Wu, Y Chen, J Nie, C Chen - Frontiers in pharmacology, 2021 - frontiersin.org
Although chemotherapy, targeted therapy and endocrine therapy decrease rate of disease
recurrence in most breast cancer patients, many patients exhibit acquired resistance …

[HTML][HTML] Advances in understanding the role of P-gp in doxorubicin resistance: Molecular pathways, therapeutic strategies, and prospects

S Mirzaei, MH Gholami, F Hashemi, A Zabolian… - Drug Discovery …, 2022 - Elsevier
Abstract P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX)
resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2 …

Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp)

H Zhang, H Xu, CR Ashby Jr, YG Assaraf… - Medicinal research …, 2021 - Wiley Online Library
Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer
chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP …

Natural products as multidrug resistance modulators in cancer

A Kumar, V Jaitak - European journal of medicinal chemistry, 2019 - Elsevier
Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical
practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors …

Nanotechnology-empowered strategies in treatment of skin cancer

J Chandra, N Hasan, N Nasir, S Wahab… - Environmental …, 2023 - Elsevier
In current scenario skin cancer is a serious condition that has a significant impact on world
health. Skin cancer is divided into two categories: melanoma skin cancer (MSC) and non …

Application of solid lipid nanoparticles to improve the efficiency of anticancer drugs

L Bayón-Cordero, I Alkorta, L Arana - Nanomaterials, 2019 - mdpi.com
Drug delivery systems have opened new avenues to improve the therapeutic effects of
already-efficient molecules. Particularly, Solid Lipid Nanoparticles (SLNs) have emerged as …

[HTML][HTML] Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures

NH Khan, M Mir, L Qian, M Baloch, MFA Khan… - Journal of Advanced …, 2022 - Elsevier
Background Skin cancer has been the leading type of cancer worldwide. Melanoma and
non-melanoma skin cancers are now the most common types of skin cancer that have been …

Advances and limitations of antibody drug conjugates for cancer

CM Mckertish, V Kayser - Biomedicines, 2021 - mdpi.com
The popularity of antibody drug conjugates (ADCs) has increased in recent years, mainly
due to their unrivalled efficacy and specificity over chemotherapy agents. The success of the …

Advanced applications of cerium oxide based nanozymes in cancer

N Feng, Y Liu, X Dai, Y Wang, Q Guo, Q Li - RSC advances, 2022 - pubs.rsc.org
Cerium oxide nanozymes have emerged as a new type of bio-antioxidants in recent years.
CeO2 nanozymes possess enzyme mimetic activities with outstanding free radical …