Hearing loss is a significant health problem that can result from a variety of exogenous
insults that generate oxidative stress and inflammation. This can produce cellular damage …

The conversion of force into an electrical cellular signal is mediated by the opening of
different types of mechanosensitive ion channels (MSCs), including TREK/TRAAK K 2P …

The initial step in the sensory transduction pathway underpinning hearing and balance in
mammals involves the conversion of force into the gating of a mechanosensory transduction …

Summary Transmembrane channel-like (TMC) 1 and 2 are required for the
mechanotransduction of mouse inner ear hair cells and localize to the site of …

The cochlea, a coiled structure located in the ventral region of the inner ear, acts as the
primary structure for the perception of sound. Along the length of the cochlear spiral is the …

Organisms of all phyla express mechanosensitive ion channels with a wide range of
physiological functions. In recent years, several classes of mechanically gated ion channels …

Summary TMC1 and TMC2 (TMC1/2) have been proposed to form the pore of the
mechanotransduction channel of cochlear hair cells. Here, we show that TMC1/2 cannot …

Aminoglycosides (AGs) are commonly used antibiotics that cause deafness through the
irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then …

Sound-induced mechanical stimuli are detected by elaborate mechanosensory transduction
(MT) machinery in highly specialized hair cells of the inner ear. Genetic studies of inherited …

Mutations in myosin-VIIa (MYO7A) cause Usher syndrome type 1, characterized by
combined deafness and blindness. MYO7A is proposed to function as a motor that tensions …