Melatonin, along with its metabolites, have long been known to significantly reduce the
oxidative stress burden of aging cells or cells exposed to toxins. Oxidative damage is a …

Melatonin, more commonly known as the sleep hormone, is mainly secreted by the pineal
gland in dark conditions and regulates the circadian rhythm of the organism. Its intrinsic …

Diabetic retinopathy (DR), a microvascular complication of diabetes mellitus (DM), remains
as one of the major causes of vision loss worldwide. The release of pro-inflammatory …

There are several pathologies, syndromes, and physiological processes in which autophagy
is involved. This process of self‐digestion that cells trigger as a survival mechanism is …

Neuropathic pain is a common and debilitating modality of chronic pain induced by a lesion
or disease of the somatosensory nervous system. Albeit the elucidation of numerous …

Chemotherapy-induced peripheral neuropathy (CIPN) is a somatosensory axonopathy in
cancer patients receiving any of a variety of widely-use antitumor agents. CIPN can lead to …

Background Oxaliplatin is one of the first-line drugs in solid tumors treatment. However,
neuropathy is a devastating side effect leading to poor compliance and treatment cessation …

Introduction: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease associated
with disruption of alveolar epithelial cell layer and expansion of fibroblasts/myofibroblasts …

Although oxaliplatin is an effective chemotherapeutic drug for colorectal cancer (CRC)
treatment, patients often develop resistance to it. Therefore, a new strategy for CRC …

The fact that oxaliplatin (OXL), a platinum-based chemotherapeutic drug, causes severe
neuropathy greatly limits its clinical use. This study investigated the effects of lycopene, a …