Bleeding complications arising from trauma, surgery, and as congenital, disease‐
associated, or drug‐induced blood disorders can cause significant morbidities and …

The conjugation of biomolecules can impart materials with the bioactivity necessary to
modulate specific cell behaviors. While the biological roles of particular polypeptide …

Venous thrombi, fibrin-and rbc-rich clots triggered by inflammation and blood stasis, underlie
devastating, and sometimes fatal, occlusive events. During intravascular fibrin deposition …

Factor XIII (FXIII) is a transglutaminase enzyme that catalyses the formation of ε-(γ-glutamyl)
lysyl isopeptide bonds into protein substrates. The plasma form, FXIIIA2B2, has an …

Abstract Factor XIII (a)[FXIII (a)] stabilizes clots and increases resistance to fibrinolysis and
mechanical disruption. FXIIIa also mediates red blood cell (RBC) retention in contracting …

As the third most common vascular disease, venous thromboembolism is associated with
significant mortality and morbidity. Pathogenesis underlying venous thrombosis is still not …

Over the last two decades, it became evident that factor XIII (FXIII) is not only a crucial
determinant of clot characteristics but also has potentially important functions in many …

Arterial and venous thromboses are major contributors to coagulation-associated morbidity
and mortality. Greater understanding of mechanisms leading to thrombus formation and …

Significant evidence suggests that reversible oxidation of methionine residues provides a
mechanism capable of scavenging reactive species, thus creating a cycle with catalytic …

Transglutaminases (TGs) are a family of protein cross-linking enzymes that are capable of
stiffening and insolubilizing proteins and creating protein networks, and thereby altering …