Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis

Y Takahata, H Hagino, A Kimura, M Urushizaki… - International Journal of …, 2022 - mdpi.com
Owing to the rapid aging of society, the numbers of patients with joint disease continue to
increase. Accordingly, a large number of patients require appropriate treatment for …

New genetic loci link adipose and insulin biology to body fat distribution

D Shungin, TW Winkler, DC Croteau-Chonka… - Nature, 2015 - nature.com
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Stem cell-based tissue engineering approaches for musculoskeletal regeneration

PT Brown, AM Handorf, W Bae Jeon… - Current pharmaceutical …, 2013 - ingentaconnect.com
The field of regenerative medicine and tissue engineering is an ever evolving field that holds
promise in treating numerous musculoskeletal diseases and injuries. An important impetus …

CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383

LN Reynard, C Bui, CM Syddall, J Loughlin - Human genetics, 2014 - Springer
GDF5 encodes an extracellular signalling molecule that is essential for normal skeletal
development. The rs144383 C to T SNP located in the 5ʹUTR of this gene is functional and …

Fabrication of a Cu/Zn co-incorporated calcium phosphate scaffold-derived GDF-5 sustained release system with enhanced angiogenesis and osteogenesis …

D Xiao, F Yang, Q Zhao, S Chen, F Shi, X Xiang… - RSC …, 2018 - pubs.rsc.org
Synthetic scaffolds with multifunctional properties, including angiogenesis and osteogenesis
capacities, play an essential role in accelerating bone regeneration. In this study, various …

An investigation of equine mesenchymal stem cell characteristics from different harvest sites: more similar than not

KG Lombana, LR Goodrich, JN Phillips… - Frontiers in Veterinary …, 2015 - frontiersin.org
Diseases of the musculoskeletal system are a major cause of loss of use and retirement in
sport horses. The use of bone marrow-derived mesenchymal stem cells (BMDMSCs) for …

Directed differentiation and paracrine mechanisms of mesenchymal stem cells: potential implications for tendon repair and regeneration

B Zhang, Q Luo, A Halim, Y Ju… - Current Stem Cell …, 2017 - ingentaconnect.com
Background: Tendon is composed of connective tissue, is able to retract with high tensile
force, and plays a significant role in musculoskeletal motion. However, inappropriate …

[HTML][HTML] Emerging roles of circular RNAs in stem cells

M Wang, J Wu, P Wu, Y Li - Genes & Diseases, 2023 - Elsevier
Circular RNAs (circRNAs) are a novel class of noncoding RNAs that widely exist in
eukaryotes. As a new focus in the field of molecular regulation, circRNAs have attracted …

The effects of PPAR-γ inhibition on gene expression and the progression of induced osteogenic differentiation of human mesenchymal stem cells

C Granéli, C Karlsson, H Brisby, A Lindahl… - Connective tissue …, 2014 - Taylor & Francis
Mesenchymal stem cells (MSCs) can differentiate into several cell types, such as osteoblasts
and adipocytes, both in vitro and in vivo. Although these two differentiation pathways are …

生长分化因子5 诱导间充质干细胞多向分化的作用与问题

李飞非, 邓江 - 中国组织工程研究, 2024 - cjter.com
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|第19期|2024年7月 中国组织工程研究 Chinese Journal of Tissue Engineering Research …