The impaired ability of the heart to relax and stretch to accommodate venous return is
generally understood to represent a state of “diastolic dysfunction” and often described …

The giant protein titin is an essential component of muscle sarcomeres. A single titin
molecule spans half a sarcomere and mediates diverse functions along its length by virtue of …

Cardiometabolic syndromes including diabetes and obesity are associated with occurrence
of heart failure with diastolic dysfunction. There are no specific treatments for diastolic …

Alternative splicing allows a single gene to produce a variety of protein isoforms. Changes in
splicing isoform usage characterize virtually every stage of the differentiation process and …

Heart failure with preserved ejection fraction (HFpEF) is a major public health challenge,
affecting millions worldwide and placing a significant burden on healthcare systems due to …

The Frank-Starling law states that the heart's stroke volume increases with greater preload
due to increased venous return, allowing the heart to adapt to varying circulatory demands …

Both diastolic filling and systolic pumping of the heart are dependent on the passive stiffness
characteristics of various mechanical elements of myocardium. However, the specific …

Cardiac microtubules have recently been implicated in mechanical dysfunction during heart
failure. However, systemic intolerance and non-cardiac effects of microtubule …

This comment summarizes and discusses the key findings of the recent publication by
Loescher, CM, Freundt, JK, Unger, A. et al. Titin governs myocardial passive stiffness with …

Abstract The Frank-Starling law states that the heart's stroke volume increases with greater
preload due to increased venous return, allowing the heart to adapt to varying circulatory …