The Martini model, a coarse‐grained force field for molecular dynamics simulations, has
been around for nearly two decades. Originally developed for lipid‐based systems by the …

In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …

The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we
identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide …

ABSTRACT The lipid molecule phosphatidylinositol (4, 5)-bisphosphate [PI (4, 5) P 2]
controls all aspects of plasma membrane (PM) function in animal cells, from its selective …

Understanding lipid dynamics and function, from the level of single, isolated molecules to
large assemblies, is more than ever an intensive area of research. The interactions of lipids …

Coarse-grained (CG) protein models have become indispensable tools for studying many
biological protein details, from conformational dynamics to the organization of protein macro …

Bioluminescence and fluorescence resonance energy transfer (BRET and FRET) together
with the proximity ligation method revealed the existence of G-protein-coupled receptors …

G protein-coupled receptors (GPCRs) are lipid-regulated transmembrane proteins that play
a central role in cell signaling and pharmacology. Although the role of membrane lipids in …

Variants in the gap junction beta-2 (GJB2) gene are the most common cause of hereditary
hearing impairment. However, how GJB2 variants lead to local physicochemical and …

YidC belongs to an evolutionarily conserved family of insertases, YidC/Oxa1/Alb3, in
bacteria, mitochondria, and chloroplasts, respectively. Unlike Gram-negative bacteria, Gram …