Airborne transmission of COVID-19: aerosol dispersion, lung deposition, and virus-receptor interactions

YY Zuo, WE Uspal, T Wei - ACS nano, 2020 - ACS Publications
Coronavirus disease 2019 (COVID-19), due to infection by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is now causing a global pandemic. Aerosol …

Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

[HTML][HTML] Chemicals inhaled from spray cleaning and disinfection products and their respiratory effects. A comprehensive review

PA Clausen, M Frederiksen, CS Sejbæk… - International journal of …, 2020 - Elsevier
Spray cleaning and disinfection products have been associated with adverse respiratory
effects in professional cleaners and among residents doing domestic cleaning. This review …

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

S Halappanavar, S Van Den Brule, P Nymark… - Particle and Fibre …, 2020 - Springer
Toxicity testing and regulation of advanced materials at the nanoscale, ie nanosafety, is
challenged by the growing number of nanomaterials and their property variants requiring …

[HTML][HTML] Per-and polyfluoroalkyl substances (PFASs) modify lung surfactant function and pro-inflammatory responses in human bronchial epithelial cells

JB Sørli, M Låg, L Ekeren, J Perez-Gil, LS Haug… - Toxicology in Vitro, 2020 - Elsevier
The toxicity of some per-and polyfluoroalkyl substances (PFASs), such as perfluorooctane
sulfonate (PFOS) and perfluorooctanoic acid (PFOA) has been studied thoroughly, showing …

Toward rigorous materials production: New approach methodologies have extensive potential to improve current safety assessment practices

P Nymark, M Bakker, S Dekkers, R Franken… - Small, 2020 - Wiley Online Library
Advanced material development, including at the nanoscale, comprises costly and complex
challenges coupled to ensuring human and environmental safety. Governmental agencies …

[HTML][HTML] An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function

E Da Silva, U Vogel, KS Hougaard, J Pérez-Gil… - Current research in …, 2021 - Elsevier
Inhaled substances, such as consumer products, chemicals at the workplace, and
nanoparticles, can affect the lung function in several ways. In this paper, we explore the …

Aggregation state of metal-based nanomaterials at the pulmonary surfactant film determines biophysical inhibition

Y Yang, L Xu, S Dekkers, LG Zhang… - … science & technology, 2018 - ACS Publications
Metal-based nanomaterials (MNMs) represent a large category of the engineered
nanomaterials, and have been extensively used to enhance the electrical, optical, and …

[HTML][HTML] Bile salt enhancers for inhalation: correlation between in vitro and in vivo lung effects

JB Sørli, KB Sivars, E Da Silva, KS Hougaard… - International Journal of …, 2018 - Elsevier
The lungs have potential as a means of systemic drug delivery of macromolecules. Systemic
delivery requires crossing of the air-blood barrier, however with molecular size-dependent …

[HTML][HTML] Risk assessment of consumer spray products using in vitro lung surfactant function inhibition, exposure modelling and chemical analysis

JB Sørli, S Sengupta, ACØ Jensen, V Nikiforov… - Food and Chemical …, 2022 - Elsevier
Consumer spray products release aerosols that can potentially be inhaled and reach the
deep parts of the lungs. A thin layer of liquid, containing a mixture of proteins and lipids …