Discovery of shared genomic loci using the conditional false discovery rate approach
In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …
the statistical power has improved and thousands of trait-associated variants have been …
Risk of dementia in bipolar disorder and the interplay of lithium: a systematic review and meta‐analyses
Objectives To assess whether bipolar disorder (BD) increases the rate of dementia and
whether lithium is related to a lower risk of dementia in BD. Methods A total of 10 studies …
whether lithium is related to a lower risk of dementia in BD. Methods A total of 10 studies …
Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease
J Lake, C Warly Solsberg, JJ Kim, J Acosta-Uribe… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …
out in European ancestry individuals despite the known variation in genetic architecture and …
Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways
Recent genetic studies have identified variants associated with bipolar disorder (BD), but it
remains unclear how brain gene expression is altered in BD and how genetic risk for BD …
remains unclear how brain gene expression is altered in BD and how genetic risk for BD …
Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank
In just over a decade, advances in genome-wide association studies (GWAS) have offered
an approach to stratify individuals based on genetic risk for disease. Using recent …
an approach to stratify individuals based on genetic risk for disease. Using recent …
Genetic contributions to bipolar disorder: current status and future directions
KS O'Connell, BJ Coombes - Psychological Medicine, 2021 - cambridge.org
Bipolar disorder (BD) is a highly heritable mental disorder and is estimated to affect about 50
million people worldwide. Our understanding of the genetic etiology of BD has greatly …
million people worldwide. Our understanding of the genetic etiology of BD has greatly …
Identification of hub genes and key pathways associated with bipolar disorder based on weighted gene co-expression network analysis
Y Liu, HY Gu, J Zhu, YM Niu, C Zhang… - Frontiers in physiology, 2019 - frontiersin.org
Bipolar disorder (BD) is a complex mental disorder with high mortality and disability rates
worldwide; however, research on its pathogenesis and diagnostic methods remains limited …
worldwide; however, research on its pathogenesis and diagnostic methods remains limited …
Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders
Psychiatric disorders and common epilepsies are heritable disorders with a high comorbidity
and overlapping symptoms. However, the causative mechanisms underlying this …
and overlapping symptoms. However, the causative mechanisms underlying this …
Large epigenome-wide association study of childhood ADHD identifies peripheral DNA methylation associated with disease and polygenic risk burden
MA Mooney, P Ryabinin, B Wilmot, P Bhatt… - Translational …, 2020 - nature.com
Epigenetic variation in peripheral tissues is being widely studied as a molecular biomarker
of complex disease and disease-related exposures. To date, few studies have examined …
of complex disease and disease-related exposures. To date, few studies have examined …
[HTML][HTML] Brain-wide genome-wide colocalization study for integrating genetics, transcriptomics and brain morphometry in Alzheimer's disease
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases.
However, the AD mechanism has not yet been fully elucidated to date, hindering the …
However, the AD mechanism has not yet been fully elucidated to date, hindering the …