ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …

Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

Alzheimer's disease (AD) risk gene ApoE4 perturbs brain lipid homeostasis and energy
transduction. However, the cell-type-specific mechanism of ApoE4 in modulating brain lipid …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …

Background The growing body of evidence indicating the heterogeneity of Alzheimer's
disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy …

The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but
neurons do not work in isolation. Emerging evidence suggests that the intricate balance of …

Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …

Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism,
neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3 …