Osteoporosis in men is a common but often overlooked disorder by clinicians. The criterion
for osteoporosis diagnosis in men is similar to that in women—namely, a bone mineral …

Introduction Over the past few years, multiple observational studies have speculated a
potential association between inflammatory bowel disease (IBD), which includes ulcerative …

Context Mutations in the androgen receptor (AR) gene might be associated with infertility
mainly because they cause various degrees of androgen insensitivity. Objective The aim of …

A defect in the canonical Wnt-β-catenin pathway may lead to reduced bone strength and
increased fracture risk. Sclerostin is a key inhibitor of this pathway by binding to low-density …

Osteoporosis, characterized by reduced bone mass and compromised skeletal
microarchitecture, significantly increases the risk of fractures and is the most prevalent …

Mutations in the CDKN2A gene are the extremely common alteration in genetic melanoma,
with presence in 40% of families with strong family ancestor. This gene normally encodes …

1.2. Methods A comprehensive search of six electronic databases was conducted up to and
including March 15, 2021. Controlled studies with a duration of at least six months in which …

Next-generation sequencing (NGS) has enormously improved the identification of disease-
candidate genetic variants. However, most NGS studies did not tackle the functional …