Circadian rhythms and the molecular clock in cardiovascular biology and disease

S Crnko, BC Du Pré, JPG Sluijter… - Nature Reviews …, 2019 - nature.com
The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism—
circadian rhythmicity—to anticipate the daily changes caused by this rotation. The molecular …

Environmental determinants of cardiovascular disease

A Bhatnagar - Circulation research, 2017 - Am Heart Assoc
Many features of the environment have been found to exert an important influence on
cardiovascular disease (CVD) risk, progression, and severity. Changes in the environment …

Impact of circadian disruption on cardiovascular function and disease

SL Chellappa, N Vujovic, JS Williams… - Trends in Endocrinology …, 2019 - cell.com
The circadian system, that is ubiquitous across species, generates∼ 24 h rhythms in
virtually all biological processes, and allows them to anticipate and adapt to the 24 h …

Circadian integration of metabolism and energetics

J Bass, JS Takahashi - Science, 2010 - science.org
Circadian clocks align behavioral and biochemical processes with the day/night cycle.
Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms …

The effects of light at night on circadian clocks and metabolism

LK Fonken, RJ Nelson - Endocrine reviews, 2014 - academic.oup.com
Most organisms display endogenously produced∼ 24-hour fluctuations in physiology and
behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional …

Coordination of circadian timing in mammals

SM Reppert, DR Weaver - Nature, 2002 - nature.com
Time in the biological sense is measured by cycles that range from milliseconds to years.
Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most …

High-fat diet disrupts behavioral and molecular circadian rhythms in mice

A Kohsaka, AD Laposky, KM Ramsey, C Estrada… - Cell metabolism, 2007 - cell.com
The circadian clock programs daily rhythms and coordinates multiple behavioral and
physiological processes, including activity, sleep, feeding, and fuel homeostasis. Recent …

Oxidative stress in ischemic heart disease

A Kibel, AM Lukinac, V Dambic, I Juric… - Oxidative medicine …, 2020 - Wiley Online Library
One of the novel interesting topics in the study of cardiovascular disease is the role of the
oxidation system, since inflammation and oxidative stress are known to lead to …

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

Y Nakahata, M Kaluzova, B Grimaldi, S Sahar… - Cell, 2008 - cell.com
Circadian rhythms govern a large array of metabolic and physiological functions. The central
clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its …

Extensive and divergent circadian gene expression in liver and heart

KF Storch, O Lipan, I Leykin, N Viswanathan, FC Davis… - Nature, 2002 - nature.com
Many mammalian peripheral tissues have circadian clocks,,,; endogenous oscillators that
generate transcriptional rhythms thought to be important for the daily timing of physiological …