Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

H Sies, VV Belousov, NS Chandel, MJ Davies… - … reviews Molecular cell …, 2022 - nature.com
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

Fluorescent proteins and genetically encoded biosensors

M Wang, Y Da, Y Tian - Chemical Society Reviews, 2023 - pubs.rsc.org
The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

A designed photoenzyme for enantioselective [2+ 2] cycloadditions

JS Trimble, R Crawshaw, FJ Hardy, CW Levy… - Nature, 2022 - nature.com
The ability to program new modes of catalysis into proteins would allow the development of
enzyme families with functions beyond those found in nature. To this end, genetic code …

Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

J Zhang, CM Simpson, J Berner, HB Chong, J Fang… - Cell, 2023 - cell.com
Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

Full-coverage regulations of autophagy by ROS: from induction to maturation

J Zhou, XY Li, YJ Liu, J Feng, Y Wu, HM Shen, GD Lu - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is an evolutionarily well-conserved recycling process in
response to stress conditions, including a burst of reactive oxygen species (ROS) …

Optogenetics at the presynapse

BR Rost, J Wietek, O Yizhar, D Schmitz - Nature neuroscience, 2022 - nature.com
Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …

GSH/pH Dual Activatable Cross‐linked and Fluorinated PEI for Cancer Gene Therapy Through Endogenous Iron De‐Hijacking and in Situ ROS Amplification

S Yang, Y Wu, W Zhong, R Chen, M Wang… - Advanced …, 2024 - Wiley Online Library
Ferroptosis‐related cancer therapy is limited by insufficient Fe2+/Fe3+ redox pair and
hydrogen peroxide (H2O2) for producing lethal hydroxyl radicals (· OH). Although …

Tailoring photosensitive ROS for advanced photodynamic therapy

DL Sai, J Lee, DL Nguyen, YP Kim - Experimental & molecular …, 2021 - nature.com
Photodynamic therapy (PDT) has been considered a noninvasive and cost-effective
modality for tumor treatment. However, the complexity of tumor microenvironments poses …

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Z Zhou, J Song, L Nie, X Chen - Chemical society reviews, 2016 - pubs.rsc.org
The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the
efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of …

New photosensitizers for photodynamic therapy

H Abrahamse, MR Hamblin - Biochemical Journal, 2016 - portlandpress.com
Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since
become a well-studied therapy for cancer and various non-malignant diseases including …