Neutrophils have long been considered as cells playing a crucial role in the immune
defence against invading pathogens. Accumulating evidence strongly supported the direct …

Neutrophils are the most abundant circulating leukocytes in humans and the first immune
cells recruited at the site of inflammation. Classically perceived as short-lived effector cells …

Neutrophil extracellular traps (NETs) participate in the rapid inhibition and clearance of
pathogens during infection; however, the molecular regulation of NET formation remains …

Psoriasis is a chronic inflammatory skin condition associated with immune dysregulation.
The immunologic cascade mediated by the interleukin (IL)-17 pathway plays a critically …

The skin is the largest organ of the body. The establishment of immunological memory in the
skin is a crucial component of the adaptive immune response. Once naive T cells are …

Macrophages acquire distinct phenotypes during tissue stress and inflammatory responses.
Macrophages are roughly categorized into two different subsets named inflammatory M1 …

Matrix mechanics regulate essential cell behaviors through mechanotransduction, and as
one of its most important elements, substrate stiffness was reported to regulate cell functions …

Interleukin-33 (IL-33), a member of the IL-1 cytokine family and a multifunctional cytokine,
plays critical roles in maintaining host homeostasis and in pathological conditions, such as …

Pancreatic ductal adenocarcinoma (PDAC) presents a 5-year overall survival rate of 11%,
despite efforts to improve clinical outcomes in the past two decades. Therapeutic resistance …

The importance of IL‐23 and its specific receptor, IL‐23R, in the pathogenesis of several
chronic inflammatory diseases has been established, but the underlying pathological …