The role of opioid receptors in modulating Alzheimer's Disease
P Tanguturi, JM Streicher - Frontiers in Pharmacology, 2023 - frontiersin.org
Alzheimer's disease (AD) is a complex neurological disorder characterized by accumulation
of amyloid plaques and neurofibrillary tangles. Long term investigation of AD pathogenesis …
of amyloid plaques and neurofibrillary tangles. Long term investigation of AD pathogenesis …
Realization of amyloid-like aggregation as a common cause for pathogenesis in diseases
S Naskar, N Gour - Life, 2023 - mdpi.com
Amyloids were conventionally referred to as extracellular and intracellular accumulation of
Aβ42 peptide, which causes the formation of plaques and neurofibrillary tangles inside the …
Aβ42 peptide, which causes the formation of plaques and neurofibrillary tangles inside the …
[HTML][HTML] The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function
J Zhang, M Pandey, A Awe, N Lue, C Kittock… - The American Journal of …, 2024 - cell.com
Disease-associated variants identified from genome-wide association studies (GWASs)
frequently map to non-coding areas of the genome such as introns and intergenic regions …
frequently map to non-coding areas of the genome such as introns and intergenic regions …
Stress granule‐mediated RNA regulatory mechanism in Alzheimer's disease
K Sato, K Takayama, S Inoue - Geriatrics & Gerontology …, 2024 - Wiley Online Library
Living organisms experience a range of stresses. To cope effectively with these stresses,
eukaryotic cells have evolved a sophisticated mechanism involving the formation of stress …
eukaryotic cells have evolved a sophisticated mechanism involving the formation of stress …
Neuroprotective Effect of Combined Treatment with Epigallocatechin 3-Gallate and Melatonin on Familial Alzheimer's Disease PSEN1 E280A Cerebral Spheroids …
V Soto-Mercado, M Mendivil-Perez… - Journal of …, 2024 - journals.sagepub.com
Background: Familial Alzheimer's disease (FAD) is caused by mutations in one or more of 3
genes known as AβPP, PSEN1, and PSEN2. There are currently no effective therapies for …
genes known as AβPP, PSEN1, and PSEN2. There are currently no effective therapies for …
[HTML][HTML] Advances in the cell biology of the trafficking and processing of amyloid precursor protein: impact of familial Alzheimer's disease mutations
J Wang, L Fourriere, PA Gleeson - Biochemical Journal, 2024 - pmc.ncbi.nlm.nih.gov
The production of neurotoxic amyloid-β peptides (Aβ) is central to the initiation and
progression of Alzheimer's disease (AD) and involves sequential cleavage of the amyloid …
progression of Alzheimer's disease (AD) and involves sequential cleavage of the amyloid …
Amyloid-ß plaque formation and BACE1 accumulation in the brains of a 5xFAD Alzheimer's disease mouse model is associated with altered distribution and not …
K Dominko, A Rastija, K Smiljanic, A Mladenovic… - Mechanisms of ageing …, 2022 - Elsevier
The formation of amyloid-ß peptides (Aß), that accumulate in Alzheimer's disease (AD)
brains, involves proteolytic processing of the amyloid precursor protein (APP) firstly by ß …
brains, involves proteolytic processing of the amyloid precursor protein (APP) firstly by ß …
Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol
V Rudajev, J Novotny - Cell & Bioscience, 2023 - Springer
Amyloid β is considered a key player in the development and progression of Alzheimer's
disease (AD). Many studies investigating the effect of statins on lowering cholesterol suggest …
disease (AD). Many studies investigating the effect of statins on lowering cholesterol suggest …