Progesterone is essential for pregnancy maintenance and menstrual cycle regulation.
Hormone action has been primarily ascribed to the well-characterized classical signaling …

Around 70% of all breast cancers are estrogen receptor alpha positive and hence their
development is highly dependent on estradiol. While the invention of endocrine therapies …

The human epidermal growth factor receptor 2 (HER2) is a major player in the survival and
proliferation of tumour cells and is overexpressed in up to 30% of breast cancer cases. A …

Background Estrogen and progesterone are potent breast mitogens. In addition to steroid
hormones, multiple signaling pathways input to estrogen receptor (ER) and progesterone …

Approximately 15–20% of breast cancers (BC) show either membrane overexpression of
ErbB-2 (MErbB-2), a member of the ErbBs family of receptor tyrosine kinases, or ERBB2 …

Membrane overexpression of the receptor tyrosine kinase ErbB-2 (MErbB-2) accounts for a
clinically aggressive breast cancer (BC) subtype (ErbB-2-positive) with increased incidence …

Human epidermal growth factor receptor 2 (HER2) is known as a potential target for both
cancer treatment and diagnosis. One of the most interesting HER2-targeted therapeutics is …

The ovarian steroid hormone progesterone and its nuclear receptor, the Progesterone
Receptor (PR), play an essential role in the regulation of cell proliferation and differentiation …

Progesterone and its receptor, PR, are essential for uterine leiomyoma (LM, aka, fibroid)
tumorigenesis, but the underlying cellular and molecular mechanisms remain unclear. The …

Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and
progesterone receptors and the lack of membrane overexpression or gene amplification of …