Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Cancer stem-like cells (CSCs) contribute to the tumorigenicity, progression, and
chemoresistance of cancers. It is not known whether CSCs arise from normal stem cells or if …

The Wnt1 protein, a secreted ligand that activates Wnt signaling pathways, contributes to the
self-renewal of cancer stem cells (CSCs) and thus may be a major determinant of tumor …

Cancer stem cells (CSCs) are thought to drive uncontrolled tumor growth, and the existence
of CSCs has recently been proven by direct experimental evidence, including tracing cell …

Embryonic stem cell (ESC) markers are molecules specifically expressed in ES cells.
Understanding of the functions of these markers is critical for characterization and …

Wnt/β-catenin signaling plays an important role not only in cancer, but also in cancer stem
cells. In this study, we found that β-catenin and OCT-4 was highly expressed in cisplatin …

The human OCT4 gene can generate at least three transcripts (OCT4A, OCT4B, and
OCT4B1) and four protein isoforms (OCT4A, OCT4B-190, OCT4B-265, and OCT4B-164) by …

OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially
encode two spliced variants, designated OCT4A and OCT4B. We have examined the …

Purpose: The existence of tumor-initiating cells in breast cancer has profound implications
for cancer therapy. In this study, we investigated the sensitivity of tumor-initiating cells …

Uncontrolled self-renewal plays a direct function in the progression of different types of
carcinomas. The same molecular pathway that manages self-renewal in normal stem cells …