Recent combat experience reignited interest in transfusing whole blood (WB) for patients
with life‐threatening bleeding. US Army data indicate that WB transfusion is associated with …

The beginning of the modern era of blood transfusion coincided with World War II and the
resultant need for massive blood replacement. Soon thereafter, the hazards of transfusion …

Graft versus host disease (GVHD), mediated by donor T cells, is a significant source of
morbidity and mortality following allogeneic stem cell transplantation. Mesenchymal stem …

A nucleic acid-targeted photochemical treatment (PCT) using amotosalen HCl (S-59) and
ultraviolet A (UVA) light was developed to inactivate viruses, bacteria, protozoa, and …

Blood transfusion is considered safe when the infused blood is tested using state of the art
viral assays developed over the past several decades. Only rarely are known viruses like …

Pathogen reduction (PR) of platelet products increases costs and available clinical studies
are equivocal with respect to clinical and haemostatic effectiveness. We conducted a …

Acute graft-versus-host disease (aGVHD) is a life-threatening complication following
allogeneic haematopoietic stem cell transplantation (HSCT), occurring in up to 30–50% of …

Despite the increased application of aseptic techniques for blood collection and the
preparation of platelet concentrates, morbidity and mortality arising from the transfusion of …

The desire to rid the blood supply of pathogens of all types has led to the development of
many technologies aimed at the same goal—eradication of the pathogen (s) without …

Transfusion‐associated graft‐versus‐host disease (TA‐GvHD) is a rare complication of
transfusion of cellular blood components producing a graft‐versus‐host clinical picture with …