The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase
(MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress …

Cerebrovascular disease is highly prevalent and has a complex etiology and variable
pathophysiological activities. It thus poses a serious threat to human life and health …

With the use of advanced electron microscopy and molecular biology tools, several studies
have shown that autophagy is involved in the development of ischemic stroke. A series of …

Peptides and peptidomimetics are strongly re-emerging as amenable candidates in the
development of therapeutic strategies against a plethora of pathologies. In particular, these …

Background: Neuronal excitotoxicity and metabolic decline, which begin in the early stages
of Alzheimer's disease (AD), pose challenges for effective amelioration. Our previous work …

Growth arrest and DNA damage-inducible beta (Gadd45b) is directly intertwined with stress-
induced DNA repair, cell cycle arrest, survival, and apoptosis. Previous research on …

Intestinal ischemia reperfusion (I/R) may cause inflammation-, oxidative stress-, and
apoptosis-related tissue injuries and facilitate bacterial infection, leading to multiple organ …

Abstract Cell division cycle 25 (Cdc25) and mitogen-activated protein kinase kinase 7
(MKK7) are enzymes involved in intracellular signaling but can also contribute to …

Stress-activated mitogen-activated protein kinase kinase 7 (MKK7) is a member of the dual-
specificity mitogen-activated protein kinase family. In the human body, MKK7 controls …

Much evidence has proved that excitotoxicity induced by excessive release of glutamate
contributes largely to damage caused by ischemia. In view of the key role played by NMDA …