DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy
R Huang, PK Zhou - Signal transduction and targeted therapy, 2021 - nature.com
Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …
Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy
KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
Trial watch: STING agonists in cancer therapy
Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an
endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from …
endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from …
Impact of DNA damage response and repair (DDR) gene mutations on efficacy of PD-(L) 1 immune checkpoint inhibition in non–small cell lung cancer
Purpose: DNA damage response and repair (DDR) gene alterations are associated with
increased tumor-infiltrating lymphocytes, higher genomic instability, and higher tumor …
increased tumor-infiltrating lymphocytes, higher genomic instability, and higher tumor …
Targeting STING for cancer immunotherapy: from mechanisms to translation
R Huang, Q Ning, J Zhao, X Zhao, L Zeng, Y Yi… - International …, 2022 - Elsevier
Cancer immunotherapy with immune checkpoint inhibitors has achieved unprecedented
success in cancer treatment; However, only a subset of patients achieved clinical benefit …
success in cancer treatment; However, only a subset of patients achieved clinical benefit …
Agonists and Inhibitors of the cGAS-STING Pathway
X Yu, L Cai, J Yao, C Li, X Wang - Molecules, 2024 - mdpi.com
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is
pivotal in immunotherapy. Several agonists and inhibitors of the cGAS-STING pathway have …
pivotal in immunotherapy. Several agonists and inhibitors of the cGAS-STING pathway have …
[HTML][HTML] cGAS-STING pathway in oncogenesis and cancer therapeutics
The host innate immunity offers the first line of defense against infection. However, recent
evidence shows that the host innate immunity is also critical in sensing the presence of …
evidence shows that the host innate immunity is also critical in sensing the presence of …
The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
ACOD1 (also known as IRG1) has emerged as a regulator of immunometabolism that
operates by producing metabolite itaconate. Here, we report a key role of STING1 (also …
operates by producing metabolite itaconate. Here, we report a key role of STING1 (also …
The role of STING signaling in central nervous system infection and neuroinflammatory disease
LE Fritsch, C Kelly, AM Pickrell - WIREs mechanisms of disease, 2023 - Wiley Online Library
The cyclic guanosine monophosphate–adenosine monophosphate (GMP‐AMP) synthase‐
Stimulator of Interferon Genes (cGAS‐STING) pathway is a critical innate immune …
Stimulator of Interferon Genes (cGAS‐STING) pathway is a critical innate immune …
[HTML][HTML] Laboratory-scale lentiviral vector production and purification for enhanced ex vivo and in vivo genetic engineering
M Soldi, LS Sergi, G Unali, T Kerzel, I Cuccovillo… - … Therapy-Methods & …, 2020 - cell.com
Lentiviral vectors (LVs) are increasingly employed in gene and cell therapy. Standard
laboratory production of LVs is not easily scalable, and research-grade LVs often contain …
laboratory production of LVs is not easily scalable, and research-grade LVs often contain …