Systemic light chain amyloidosis

V Sanchorawala - New England Journal of Medicine, 2024 - Mass Medical Soc
Key Points Systemic Light Chain Amyloidosis Immunoglobulin light chain (AL) amyloidosis
is a rare disease that occurs when a plasma cell disorder produces monoclonal light chains …

Molecular mechanisms of amyloidosis

G Merlini, V Bellotti - New England Journal of Medicine, 2003 - Mass Medical Soc
Amyloidosis affects millions of people, as a cause of Alzheimer's disease or a complication
of dialysis, and also causes rare conditions. The many forms of the disorder have one …

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

DKV Kumar, SH Choi, KJ Washicosky… - Science translational …, 2016 - science.org
The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We
previously reported in vitro evidence suggesting that Aβ is an antimicrobial peptide. We …

Genotype and phenotype of transthyretin cardiac amyloidosis: THAOS (Transthyretin Amyloid Outcome Survey)

MS Maurer, M Hanna, M Grogan, A Dispenzieri… - Journal of the American …, 2016 - jacc.org
Background: Transthyretin amyloidosis (ATTR) is a heterogeneous disorder with multiorgan
involvement and a genetic or nongenetic basis. Objectives: The goal of this study was to …

Prognostic value of late gadolinium enhancement cardiovascular magnetic resonance in cardiac amyloidosis

M Fontana, S Pica, P Reant, A Abdel-Gadir, TA Treibel… - Circulation, 2015 - Am Heart Assoc
Background—The prognosis and treatment of the 2 main types of cardiac amyloidosis,
immunoglobulin light chain (AL) and transthyretin (ATTR) amyloidosis, are substantially …

Noncontrast magnetic resonance for the diagnosis of cardiac amyloidosis

A Baggiano, M Boldrini, A Martinez-Naharro… - Cardiovascular …, 2020 - jacc.org
Objectives This study aimed to assess the diagnostic use of native T1 to detect cardiac
amyloidosis (CA) in a large prospective cohort of patients referred for suspected systemic …

Myocardial T1 and T2 mapping: techniques and clinical applications

PK Kim, YJ Hong, DJ Im, YJ Suh… - Korean journal of …, 2017 - synapse.koreamed.org
Cardiac magnetic resonance (CMR) imaging is widely used in various medical fields related
to cardiovascular diseases. Rapid technological innovations in magnetic resonance imaging …

Diagnostic work-up in cardiomyopathies: bridging the gap between clinical phenotypes and final diagnosis. A position statement from the ESC Working Group on …

C Rapezzi, E Arbustini, ALP Caforio… - European heart …, 2013 - academic.oup.com
Abstract In 2008, The ESC Working Group on Myocardial and Pericardial Diseases
proposed an updated classification of cardiomyopathies based on morphological and …

Systemic cardiac amyloidoses: disease profiles and clinical courses of the 3 main types

C Rapezzi, G Merlini, CC Quarta, L Riva, S Longhi… - Circulation, 2009 - Am Heart Assoc
Background—Most studies of amyloidotic cardiomyopathy consider as a single entity the 3
main systemic cardiac amyloidoses: acquired monoclonal immunoglobulin light-chain (AL); …

Myocardial edema and prognosis in amyloidosis

T Kotecha, A Martinez-Naharro, TA Treibel… - Journal of the American …, 2018 - jacc.org
Background: Prognosis in light-chain (AL) and transthyretin (ATTR) amyloidosis is
influenced by cardiac involvement. ATTR amyloidosis has better prognosis than AL …