The pathological hallmarks of Parkinson's disease (PD) are the progressive loss of
dopaminergic neurons in the substantia nigra and the formation of Lewy bodies (LBs) in …

Tau protein (MAPT) is classified as a microtubule-associated protein (MAP) and is believed
to regulate the axonal microtubule arrangement. It belongs to the tau/MAP2/MAP4 family of …

Animal models constructed using pathogenic factors have significantly advanced drug
development for Alzheimer's disease (AD). These predominantly transgenic models, mainly …

The critical role of mitochondrial dysfunction in the pathological mechanisms of
neurodegenerative disorders, particularly Parkinson's disease (PD), is well established …

The prodromal phase of Parkinson's disease (PD) is characterised by many non-motor
symptoms, and these have recently been posited to be predictive of later diagnosis. Genetic …

Hyposmia is a prevalent prodromal feature of Parkinson's disease (PD), though the
neuropathology that underlies this symptom is poorly understood. Unlike the substantia …

Retinal hyperspectral imaging (HSI) is a non-invasive in vivo approach that has shown
promise in Alzheimer's disease. Parkinson's disease is another neurodegenerative disease …

Background The nigrostriatal dopamine (DA) system plays a critical role in regulating the
sleep–wake state. The relationship between baseline striatal DA transporter (DAT) specific …

Background: Sleep/wake disturbances (eg, insomnia and sleep fragmentation) are common
in neurodegenerative disorders, especially Alzheimer's disease (AD) and frontotemporal …

Background: Olfactory dysfunction is a well-known phenomenon in neurological diseases
with anosmia and hyposmia serving as clinical or preclinical indicators of Alzheimer's …