The understanding of acute respiratory distress syndrome (ARDS) has evolved greatly since
it was first described in a 1967 case series, with several subsequent updates to the definition …

According to the latest definition, sepsis is characterized by life-threatening organ
dysfunction caused by a dysregulated host response to an infection. However, this definition …

Critical illness can significantly alter the composition and function of the human microbiome,
but few studies have examined these changes over time. Here, we conduct a …

Red blood cells (RBCs), traditionally recognized for their role in transporting oxygen, play a
pivotal role in the body's immune response by expressing TLR9 and scavenging excess …

COVID-19 has significant long-term impacts, including a chronic syndrome known as long-
COVID, characterized by persistent symptoms post-recovery. The inflammatory response …

Fungal lung disease encompasses a wide spectrum of organisms and associated clinical
conditions, presenting a significant global health challenge. The type and severity of disease …

Critical illness syndromes including sepsis, acute respiratory distress syndrome, and acute
kidney injury (AKI) are associated with high in-hospital mortality and long-term adverse …

Rationale: The global burden of sepsis is concentrated in sub-Saharan Africa, where inciting
pathogens are diverse and HIV co-infection is a major driver of poor outcomes. Biological …

Background Sepsis poses a grave threat, especially among children, but treatments are
limited owing to heterogeneity among patients. We sought to test the clinical and biological …

Corticosteroids decrease the duration of organ dysfunction in a range of infectious critical
illnesses, but their risk and benefit are not fully defined using this construct. This …