Cancer has always been an enormous threat to human health and survival. Surgery,
radiotherapy, and chemotherapy could improve the survival of cancer patients, but most …

Cancer is a daunting global problem confronting the world's population. The most frequent
therapeutic approaches include surgery, chemotherapy, radiotherapy, and more recently …

Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Apoptosis deficiency is one of the most important features observed in neoplastic diseases.
The Bcl-2 family is composed of a subset of proteins that act as decisive apoptosis …

Introduction: Programmed cell death is well-orchestrated process regulated by multiple pro-
apoptotic and anti-apoptotic genes, particularly those of the Bcl-2 gene family. These genes …

Myeloid cell leukemia-1 (MCL-1), a member of antiapoptotic BCL-2 family proteins, is a key
regulator of mitochondrial homeostasis. Frequent overexpression of MCL-1 in human …

Myeloid cell leukemia-1 (MCL-1) is an anti-apoptotic BCL-2 protein that is up-regulated in
several human cancers. MCL-1 is also highly expressed in myocardium, but its function in …

Mitochondria play a critical role in apoptosis, or programmed cell death, by releasing
apoptogenic factors from the intermembrane space. This process, known as mitochondrial …

Lung cancer is the leading cause of cancer-related death worldwide with a 5-year survival
rate of less than 15%, despite significant advances in both diagnostic and therapeutic …

Apoptosis is one of the major mechanisms exhibited in response to cell death and induction
of apoptosis in tumour cells signifies a potential target for cancer therapy. Bcl-2 family …