Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro

X Wang, Q Wu, A Liu, A Anadón… - Drug metabolism …, 2017 - Taylor & Francis
Paracetamol (APAP) is one of the most widely used and popular over-the-counter analgesic
and antipyretic drugs in the world when used at therapeutic doses. APAP overdose can …

[HTML][HTML] Black seed (Nigella sativa) and its constituent thymoquinone as an antidote or a protective agent against natural or chemical toxicities

A Tavakkoli, A Ahmadi, BM Razavi… - Iranian journal of …, 2017 - ncbi.nlm.nih.gov
Abstract Nigella sativa (N. sativa), which belongs to the botanical family of Ranunculaceae,
is a widely used medicinal plant all over the world. N. sativa seeds and oil have been used …

Acetaminophen induced hepatotoxicity: An overview of the promising protective effects of natural products and herbal formulations

S Chilvery, A Yelne, A Khurana, MA Saifi, S Bansod… - Phytomedicine, 2023 - Elsevier
Background The liver plays an important role in regulating the metabolic processes and is
the most frequently targeted organ by toxic chemicals. Acetaminophen (APAP) is a well …

Лекарственные растения и медикаменты

ИД Кароматов, МР Рахматова, ВЗ Жалолова - 2020 - elibrary.ru
В монографии собраны результаты научных исследований по взаимодействию пищи и
лекарств и лекарственных средств растительного происхождения и современных …

The protective mechanism of Nigella sativa against diethylnitrosamine‐induced hepatocellular carcinoma through its antioxidant effect and EGFR/ERK1/2 signaling

YR Shahin, NM Elguindy, A Abdel Bary… - Environmental …, 2018 - Wiley Online Library
A wide variety of natural products have powerful chemopreventive effects due to their
antioxidant, antimutagenic, and anti‐inflammatory activities that enable them to arrest cell …

Nigella sativa L. and its bioactive constituents as Hepatoprotectant: a review

H Tabassum, A Ahmad… - Current pharmaceutical …, 2018 - ingentaconnect.com
Background: The pharmacological properties of Nigella sativa L. are well attributed to the
presence of bioactive compounds, mainly, thymoquinone (TQ), thymol (THY) and α hederin …

[PDF][PDF] Antibacterial activity of Nigella Sativa Linn. seeds against multiple antibiotics resistant clinical strains of Staphylococcus aureus

MT Salman, RA Khan, I Shukla - International Archives of BioMedical …, 2016 - academia.edu
Objective: Staphylococcus aureus is one of the major resistant pathogens extremely
adaptable to antibiotic pressure. Nigella sativa (black cumin) seed extracts and essential oil …

The impact of black seed oil on tramadol-induced hepatotoxicity: Immunohistochemical and ultrastructural study

NM Omar, MA Mohammed - Acta histochemica, 2017 - Elsevier
The natural herb, black seed (Nigella Sativa; NS) is one of the most important elements of
folk medicine. The aim was to evaluate the impact of Nigella Sativa Oil (NSO) on the …

Preclinical models for investigation of herbal medicines in liver diseases: Update and perspective

HY Tan, S San-Marina, N Wang, M Hong… - Evidence‐Based …, 2016 - Wiley Online Library
Liver disease results from a dynamic pathological process associated with cellular and
genetic alterations, which may progress stepwise to liver dysfunction. Commonly, liver …

Effect of Nigella sativa (black seeds) against methotrexate-induced nephrotoxicity in mice

JH Ahmed, IM Abdulmajeed - Journal of intercultural …, 2016 - pmc.ncbi.nlm.nih.gov
Aim: To evaluate the protective effect of Nigella sativa (NS) against nephrotoxicity of
methotrexate (MTX) in mice. Materials and Methods: Four groups of Swiss albino male mice …