Reconstructing functional neuronal circuits is one major challenge of central nervous system
repair. Through activation of pro-growth signaling pathways, some neurons achieve long …

The optic nerve, comprising axons from retinal ganglion cells (RGCs), is a component of the
central nervous system (CNS) that generally exhibits a limited regeneration capacity …

The retinal ganglion cells (RGCs) are the sole output neurons that connect information from
the retina to the brain. Optic neuropathies such as glaucoma, trauma, inflammation …

A critical step for functional recovery from peripheral nerve injury is for regenerating axons to
connect with their pre-injury targets. Reestablishing pre-injury target specificity is particularly …

Background Optic neuropathy is a major cause of irreversible blindness, yet the molecular
determinants that contribute to neuronal demise have not been fully elucidated. Several …

A primary challenge in spinal cord injury repair is the presence of an energy deficit,
exacerbated by the injury itself, thereby intensifying the dilemma of insufficient energy …

In discovery proteomics, as well as many other “omic” approaches, the possibility to test for
the differential abundance of hundreds (or of thousands) of features simultaneously is …

Label-free bottom-up proteomics using mass spectrometry and liquid chromatography has
long established as one of the most popular high-throughput analysis workflow for proteome …

Critical molecular pathways promote central nervous system (CNS) axon regeneration, but
can axons be guided to their correct targets in adulthood? In this issue of Developmental …

Background: Optic neuropathy (ON) is a major cause of irreversible blindness, yet the
molecular determinants that contribute to neuronal demise have not been fully elucidated …