The role of microRNA-21 (miR-21) in pathogenesis, diagnosis, and prognosis of gastrointestinal cancers: A review
MicroRNAs (miRNAs) are small non-coding RNAs regulating the expression of several
target genes. miRNAs play a significant role in cancer biology, as they can downregulate …
target genes. miRNAs play a significant role in cancer biology, as they can downregulate …
Targeting transcription factor YY1 for cancer treatment: current strategies and future directions
Simple Summary Cancer is a global health problem with severe consequences. Certain
genes, known as transcription factors (TFs), are overactive in many tumors. Targeting these …
genes, known as transcription factors (TFs), are overactive in many tumors. Targeting these …
Non-coding RNAs targeting notch signaling pathway in cancer: From proliferation to cancer therapy resistance
Cancer is a challenging to treat disease with a high mortality rate worldwide, nevertheless
advances in science has led to a decrease in the number of death cases caused by cancer …
advances in science has led to a decrease in the number of death cases caused by cancer …
[HTML][HTML] HMGA2 regulation by miRNAs in cancer: affecting cancer hallmarks and therapy response
M Hashemi, M Rashidi, K Hushmandi… - Pharmacological …, 2023 - Elsevier
High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in the
nucleus. Importantly, aberrant expression of HMGA2 occurs during carcinogenesis, and this …
nucleus. Importantly, aberrant expression of HMGA2 occurs during carcinogenesis, and this …
MiRNA-based therapies for lung cancer: Opportunities and challenges?
H Yang, Y Liu, L Chen, J Zhao, M Guo, X Zhao, Z Wen… - Biomolecules, 2023 - mdpi.com
Lung cancer is a commonly diagnosed cancer and the leading cause of cancer-related
deaths, posing a serious health risk. Despite new advances in immune checkpoint and …
deaths, posing a serious health risk. Despite new advances in immune checkpoint and …
LncRNA-miRNA interaction is involved in colorectal cancer pathogenesis by modulating diverse signaling pathways
LncRNAs function as molecular sponges for miRNAs to control their availability for targeting
mRNA molecules. This procedure indirectly regulates the expression of cancer-related …
mRNA molecules. This procedure indirectly regulates the expression of cancer-related …
lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways
Cancer drug resistance remains a formidable challenge in modern oncology, necessitating
innovative therapeutic strategies. The convergence of intricate regulatory networks involving …
innovative therapeutic strategies. The convergence of intricate regulatory networks involving …
[HTML][HTML] The lncRNA DLX6-AS1/miR-16-5p axis regulates autophagy and apoptosis in non-small cell lung cancer: a Boolean model of cell death
S Gupta, DA Silveira, JCM Mombach… - Non-coding RNA …, 2023 - Elsevier
Long non-coding RNA (lncRNA) distal-less homeobox 6 antisense RNA 1 (DLX6-AS1) is
elevated in a variety of cancers, including non-small cell lung cancer (NSCLC) and cervical …
elevated in a variety of cancers, including non-small cell lung cancer (NSCLC) and cervical …
MicroRNA-21's role in PTEN suppression and PI3K/AKT activation: Implications for cancer biology
Abstract MicroRNA-21 (miR-21) was recognized as a key figure in the intricate web of tumor
biology, with a prominent role in regulating the PTEN tumor suppressor gene and the …
biology, with a prominent role in regulating the PTEN tumor suppressor gene and the …
Long non-coding RNAs (lncRNAs) in hepatocellular carcinoma progression: Biological functions and new therapeutic targets
Liver is an important organ in body that performs vital functions such as detoxification. Liver
is susceptible to development of cancers, and hepatocellular carcinoma (HCC) is among …
is susceptible to development of cancers, and hepatocellular carcinoma (HCC) is among …