Sleep function remains controversial. Individual perspectives frame the issue of sleep
function differently. We briefly illustrate how sleep measurement and the evolution, tissue …

Ion channels represent highly attractive targets for drug discovery and are implicated in a
diverse range of disorders, in particular in the central nervous and cardiovascular systems …

Background We have collected a comprehensive set of multi-unit data on dissociated
cortical cultures. Previous studies of the development of the electrical activity of dissociated …

In vitro cultured neuronal networks coupled to microelectrode arrays (MEAs) constitute a
valuable experimental model for studying changes in the neuronal dynamics at different …

Despite the extensive use of in-vitro models for neuroscientific investigations and
notwithstanding the growing field of network electrophysiology, all studies on cultured cells …

Cognitive processes depend on synchronization and propagation of electrical activity within
and between neuronal assemblies. In vivo measurements show that the size of individual …

The historic sleep regulatory paradigm invokes “top-down” imposition of sleep on the brain
by sleep regulatory circuits. While remaining conceptually useful, many sleep phenomena …

Multineuron firing patterns are often observed, yet are predicted to be rare by models that
assume independent firing. To explain these correlated network states, two groups recently …

A clear need exists for novel nanostructured materials that are capable to meet the
performance criteria of a number of neuronal therapies including neural recording …

Although sleep is defined as a behavioral state, at the cortical level sleep has local and use-
dependent features suggesting that it is a property of neuronal assemblies requiring sleep in …