Autophagy is a conserved process that catabolizes intracellular components to maintain
energy homeostasis and to protect cells against stress. Autophagy has crucial roles during …

BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …

Decreased cognitive performance is a hallmark of brain aging, but the underlying
mechanisms and potential therapeutic avenues remain poorly understood. Recent studies …

The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

Background Spermidine administration is linked to increased survival in several animal
models. Objective The aim of this study was to test the potential association between …

Polyamines (ie, putrescine, spermidine, and spermine) are bioactive polycations capable of
binding nucleic acids and proteins and modulating signaling pathways. Polyamine functions …

Neuronal function is highly energy demanding and thus requires efficient and constant
metabolite delivery by glia. Drosophila glia are highly glycolytic and provide lactate to fuel …

The desire of eternal youth seems to be as old as mankind. However, the increasing life
expectancy experienced by populations in developed countries also involves a significantly …

Synapses are functionally distinct neuronal compartments that are critical for brain function,
with synaptic dysfunction being an early pathological feature in aging and disease. Given …

Natural polyamines (spermidine and spermine) are small, positively charged molecules that
are ubiquitously found within organisms and cells. They exert numerous (intra) cellular …