Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …

Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism
as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative …

The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of
heme degradation. Induction of HO-1 protects against the cytotoxicity of oxidative stress and …

▪ Abstract Reactive oxygen intermediates are produced in all aerobic organisms during
respiration and exist in the cell in a balance with biochemical antioxidants. Excess reactive …

Phagocyte-mediated oxidant damage to vascular endothelium is likely involved in various
vasculopathies including atherosclerosis and pulmonary leak syndromes such as adult …

Accumulating evidence suggests that oxidative stress plays a central role in the
pathogenesis of many pulmonary diseases including adult respiratory distress syndrome …

The heme biosynthetic and catabolic pathways generate pro-and antioxidant compounds,
and consequently, influence cellular sensitivity to oxidants. Heme precursors (δ …

Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

The metallothioneins (MT) are small, cysteine-rich heavy metal-binding proteins which
participate in an array of protective stress responses. Although a single essential function of …