UM Zanger, K Klein - Frontiers in genetics, 2013 - frontiersin.org
Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human liver. Expression is highly variable both between individuals and within individuals, owing to …
An accurate assessment of how quantum computers can be used for chemical simulation, especially their potential computational advantages, provides important context on how to …
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
SC Lee, BC Bennett, WX Hong, Y Fu… - Proceedings of the …, 2013 - National Acad Sciences
Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We have developed a family of steroid-based facial amphiphiles (FAs) that are structurally …
H Raunio, M Kuusisto, RO Juvonen… - Frontiers in …, 2015 - frontiersin.org
The adverse effects to humans and environment of only few chemicals are well known. Absorption, distribution, metabolism, and excretion (ADME) are the steps of pharmaco …
M Turpeinen, UM Zanger - Drug Metabolism and Drug Interactions, 2012 - degruyter.com
Abstract Cytochrome P450 (CYP) 2B6 belongs to the set of important hepatic drug- metabolizing CYPs. It makes up roughly 3%–6% of total hepatic CYP content and …
The dynamic nature of protein structures has been recognized, established, and accepted as an intrinsic fundamental property with major consequences to their function. Nowadays …
EF Johnson, CD Stout - Journal of Biological Chemistry, 2013 - ASBMB
X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These …
H Raunio, O Pentikäinen, RO Juvonen - International Journal of …, 2020 - mdpi.com
Activities of xenobiotic-metabolizing enzymes have been measured with various in vitro and in vivo methods, such as spectrophotometric, fluorometric, mass spectrometric, and …