Extensive research has yielded crucial insights into the mechanism of neurotransmitter
release, and working models for the functions of key proteins involved in release. The …

Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

Synaptotagmin-1 and neuronal SNARE proteins have central roles in evoked synchronous
neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic …

Neurotransmitter release at synapses involves a highly specialized form of membrane fusion
that is triggered by Ca2+ ions and is optimized for speed. These observations were …

Synaptic vesicles loaded with neurotransmitters are exocytosed in a soluble N-
ethylmaleimide–sensitive factor attachment protein receptor (SNARE)–dependent manner …

Docking, the initial association of secretory vesicles with the plasma membrane, precedes
formation of the SNARE complex, which drives membrane fusion. For many years, the …

Rapid neurotransmitter release depends on the Ca2+ sensor Synaptotagmin-1 (Syt1) and
the SNARE complex formed by synaptobrevin, syntaxin-1 and SNAP-25. How Syt1 triggers …

The dynamics of exocytosis are diverse and have been optimized for the functions of
synapses and a wide variety of cell types. For example, the kinetics of exocytosis varies by …

Synchronous neurotransmission is triggered when Ca2+ binds to synaptotagmin 1 (Syt1), a
synaptic-vesicle protein that interacts with SNAREs and membranes. We used single …

SNARE proteins and synaptotagmin are key components of the complex machinery that
controls Ca 2+-triggered neurotransmitter release but their mechanisms of action are under …