The global population above 60 years has been growing exponentially in the last decades,
which is accompanied by an increase in the prevalence of age‐related chronic diseases …

Oxidative stress reflects an imbalance between the production of reactive oxygen species
(ROS) and antioxidant defense systems, and it can be associated with the pathogenesis and …

Nuclear factor, erythroid 2 like 2 (NFE2L2, NRF2) is a transcription factor that regulates
various antioxidant enzymes. It plays a vital physiological role in regulating oxidative stress …

Neurodegenerative Diseases (NDs) are progressive multifactorial neurological pathologies
related to neuronal impairment and functional loss from different brain regions. Currently, no …

With a “less is more” philosophy, a series of 15 chalcone-sulfonamide hybrids were
designed anticipating synergistic anticancer activity. The aromatic sulfonamide moiety was …

Resveratrol (Res) is a polyphenolic compound that has a variety of biological functions and
activities. This study aimed to explore the mechanisms of the antioxidant and proapoptotic …

Background Nuclear factor erythroid 2-related factor 2 (Nrf2) is a classical nuclear
transcription factor that regulates the system's anti-oxidative stress response. The activation …

Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide.
Several findings suggest that correcting the dysregulated signaling pathways may offer a …

Introduction: Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a key
role in diverse gene expressions responsible for protection against oxidative stress and …

The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …