Emerging computational methods in mass spectrometry imaging

H Hu, J Laskin - Advanced Science, 2022 - Wiley Online Library
Mass spectrometry imaging (MSI) is a powerful analytical technique that generates maps of
hundreds of molecules in biological samples with high sensitivity and molecular specificity …

Multimodal imaging mass spectrometry: next generation molecular mapping in biology and medicine

EK Neumann, KV Djambazova… - Journal of the …, 2020 - ACS Publications
Imaging mass spectrometry has become a mature molecular mapping technology that is
used for molecular discovery in many medical and biological systems. While powerful by …

Native mass spectrometry imaging of proteins and protein complexes by nano-DESI

OJ Hale, HJ Cooper - Analytical chemistry, 2021 - ACS Publications
Previously, we have demonstrated native mass spectrometry imaging (native MSI) in which
the spatial distribution of proteins maintained in their native-like, folded conformations was …

Native ambient mass spectrometry imaging of ligand-bound and metal-bound proteins in rat brain

EK Sisley, OJ Hale, IB Styles… - Journal of the American …, 2022 - ACS Publications
Label-free spatial mapping of the noncovalent interactions of proteins in their tissue
environment has the potential to revolutionize life sciences research by providing …

Desorption electrospray ionization mass spectrometry imaging in discovery and development of novel therapies

T Soudah, A Zoabi, K Margulis - Mass Spectrometry Reviews, 2023 - Wiley Online Library
Desorption electrospray ionization mass spectrometry imaging (DESI‐MSI) is one of the
least specimen destructive ambient ionization mass spectrometry tissue imaging methods. It …

Advanced mass spectrometric and spectroscopic methods coupled with machine learning for in vitro diagnosis

X Chen, W Shu, L Zhao, J Wan - View, 2023 - Wiley Online Library
In vitro diagnosis (IVD) is one vital component of medical tests that detects biological
samples of tissues or bio‐fluids. Recently, mass spectrometry and spectroscopy have been …

Adipocytes provide fatty acids to acute lymphoblastic leukemia cells

J Tucci, T Chen, K Margulis, E Orgel… - Frontiers in …, 2021 - frontiersin.org
Background There is increasing evidence that adipocytes play an active role in the cancer
microenvironment. We have previously reported that adipocytes interact with acute …

Next‐generation pathology practices with mass spectrometry imaging

HH Chung, P Huang, CL Chen, C Lee… - Mass Spectrometry …, 2023 - Wiley Online Library
Mass spectrometry imaging (MSI) is a powerful technique that reveals the spatial distribution
of various molecules in biological samples, and it is widely used in pathology‐related …

Applications of ambient ionization mass spectrometry in 2020: An annual review

S Rankin‐Turner, LM Heaney - Analytical Science Advances, 2021 - Wiley Online Library
Recent developments in mass spectrometry (MS) analyses have seen a concerted effort to
reduce the complexity of analytical workflows through the simplification (or removal) of …

Advancements in Intraoperative Near-Infrared Fluorescence Imaging for Accurate Tumor Resection: A Promising Technique for Improved Surgical Outcomes and …

SK Rainu, RG Ramachandran… - ACS Biomaterials …, 2023 - ACS Publications
Clear surgical margins for solid tumor resection are essential for preventing cancer
recurrence and improving overall patient survival. Complete resection of tumors is often …