Neuropathic pain develops as a result of lesions or disease affecting the somatosensory
nervous system either in the periphery or centrally. Examples of neuropathic pain include …

The transmission and processing of pain signals relies critically on the activities of ion
channels that are expressed in afferent pain fibers. This includes voltage-gated channels, as …

Chronic pain is associated with abnormal excitability of the somatosensory system and
remains poorly treated in the clinic. Potassium (K+) channels are crucial determinants of …

Introduction: Changes in human behaviour and lifestyle over the last century have resulted
in a dramatic increase in the incidence of diabetes worldwide. Neuropathy is a common and …

Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

Molecular research on ion channels has demonstrated that many of these integral
membrane proteins associate with partner proteins, often versatile in their function, or even …

Within the potassium ion channel family, calcium activated potassium (KCa) channels are
unique in their ability to couple intracellular Ca2+ signals to membrane potential variations …

Early-life stress (ELS) is thought to cause the development of visceral pain disorders. While
some individuals are vulnerable to visceral pain, others are resilient, but the intrinsic circuit …

Calcium-activated potassium channels modulate calcium signaling cascades and
membrane potential in both excitable and non-excitable cells. In this article we will review …

The three small-conductance calcium-activated potassium (KCa2) channels and the related
intermediate-conductance KCa3. 1 channel are voltage-independent K+ channels that …