Altered gene expression is the primary molecular mechanism responsible for the
pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are …

Micro RNA s (mi RNA s) are small non‐coding RNA s that regulate gene expression at a
post‐transcriptional level via either the degradation or translational repression of a target …

Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely
investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence …

Background Bone metastasis is a leading cause of morbidity and mortality in advanced
prostate cancer (PCa). Downexpression of miR-133a-3p has been found to contribute to the …

The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP) is frequently dysregulated
in prostate adenocarcinoma (PC), via either somatic mutations or mRNA downregulation …

Cancer metastasis is the primary cause of cancer-related deaths. The seeding of primary
tumours at a secondary site is a highly inefficient process requiring substantial alterations in …

The tumor-microenvironment (TME) is an amalgamation of various factors derived from
malignant cells and infiltrating host cells, including cells of the immune system. One of the …

To understand the androgen receptor (AR) in different human malignancies, we conducted a
pan-cancer analysis of AR in different tumor tissues and association with patient survival …

Based on pioneering work by Huggins, Hodges and others, hormonal therapies have been
established as an effective approach for advanced prostate cancer (PC) for the past eight …

MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that affect
posttranscriptional regulation by binding to the 3′-untranslated region of target messenger …