Renal inflammation and fibrosis are key pathological features of acute kidney injury (AKI)
and chronic kidney disease (CKD). Smad3 is a critical mediator of TGF-β signaling and …

Diabetic nephropathy (DN) is one of the most common complications in diabetes mellitus
and the leading cause of end-stage renal disease. TGF-β is a pleiotropic cytokine and has …

TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis.
TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects …

Beyond the emerging field of oncological ultrasound molecular imaging, the recent
significant advancements in ultrasound and contrast agent technology have paved the way …

Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD).
Transforming growth factor-β (TGF-β) has been long considered as a key mediator of renal …

Renal fibrosis is a common characteristic of chronic kidney disease (CKD). Aberrant and
excessive depositions of extracellular matrix (ECM) proteins in both glomeruli and interstitial …

TGF-β1 has been long considered as a key mediator in renal fibrosis and induces renal
scarring largely by activating its downstream Smad signaling pathway. Interestingly, while …

TGF-β/Smad3 signaling promotes fibrosis, but the development of therapeutic interventions
involving this pathway will require the identification and ultimate targeting of downstream …

Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial
repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular …

Transforming growth factor-β (TGF-β) is generally considered as a central mediator of fibrotic
diseases. Indeed, much focus has been placed on inhibiting TGF-β and its downstream …