JAK–STAT pathway targeting for the treatment of inflammatory bowel disease

A Salas, C Hernandez-Rocha, M Duijvestein… - Nature reviews …, 2020 - nature.com
Cytokines are involved in intestinal homeostasis and pathological processes associated
with inflammatory bowel disease (IBD). The biological effects of cytokines, including several …

The mucosal immune system of teleost fish

I Salinas - Biology, 2015 - mdpi.com
Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

TCR and inflammatory signals tune human MAIT cells to exert specific tissue repair and effector functions

T Leng, HD Akther, CP Hackstein, K Powell, T King… - Cell reports, 2019 - cell.com
MAIT cells are an unconventional T cell population that can be activated through both TCR-
dependent and TCR-independent mechanisms. Here, we examined the impact of …

Bystander CD4+ T cells: crossroads between innate and adaptive immunity

HG Lee, MJ Cho, JM Choi - Experimental & molecular medicine, 2020 - nature.com
T cells are the central mediators of both humoral and cellular adaptive immune responses.
Highly specific receptor-mediated clonal selection and expansion of T cells assure antigen …

Upper respiratory tract mucosal immunity for SARS-CoV-2 vaccines

R Fraser, A Orta-Resendiz, A Mazein… - Trends in molecular …, 2023 - cell.com
SARS-CoV-2 vaccination significantly reduces morbidity and mortality, but has less impact
on viral transmission rates, thus aiding viral evolution, and the longevity of vaccine-induced …

Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin

AH Verma, JP Richardson, C Zhou, BM Coleman… - Science …, 2017 - science.org
Candida albicans is a dimorphic commensal fungus that causes severe oral infections in
immunodeficient patients. Invasion of C. albicans hyphae into oral epithelium is an essential …

[HTML][HTML] Immunity to gastrointestinal nematode infections

D Sorobetea, M Svensson-Frej, R Grencis - Mucosal Immunology, 2018 - Elsevier
Numerous species of nematodes have evolved to inhabit the gastrointestinal tract of animals
and humans, with over a billion of the world's population infected with at least one species …

A single-cell gene-expression profile reveals inter-cellular heterogeneity within human monocyte subsets

ST Gren, TB Rasmussen, S Janciauskiene… - PloS one, 2015 - journals.plos.org
Human monocytes are a heterogeneous cell population classified into three different
subsets: Classical CD14++ CD16-, intermediate CD14++ CD16+, and non-classical CD14+ …

[HTML][HTML] TL1A (TNFSF15) and DR3 (TNFRSF25): a co-stimulatory system of cytokines with diverse functions in gut mucosal immunity

V Valatas, G Kolios, G Bamias - Frontiers in immunology, 2019 - frontiersin.org
TL1A and its functional receptor DR3 are members of the TNF/TNFR superfamilies of
proteins. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals …

CD4 TRM Cells Following Infection and Immunization: Implications for More Effective Vaccine Design

MM Wilk, KHG Mills - Frontiers in immunology, 2018 - frontiersin.org
The induction of immunological memory, which is mediated by memory T and B cells, is
central to adaptive protective immunity to pathogens induced by previous infection and is the …