Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation in Pseudomonas aeruginosa

LZ Ma, D Wang, Y Liu, Z Zhang… - Annual review of …, 2022 - annualreviews.org
Microbial communities enmeshed in a matrix of macromolecules, termed as biofilms, are the
natural setting of bacteria. Exopolysaccharide is a critical matrix component of biofilms …

Genetic regulation, biosynthesis and applications of extracellular polysaccharides of the biofilm matrix of bacteria

S Das - Carbohydrate polymers, 2022 - Elsevier
Bacterial biofilm formation is dependent mainly on the decision-making process of the two
key factors of the gene regulatory network, namely the Quorum Sensing (QS) system and bis …

Strategy to combat biofilms: a focus on biofilm dispersal enzymes

S Wang, Y Zhao, AP Breslawec, T Liang… - npj Biofilms and …, 2023 - nature.com
Bacterial biofilms, which consist of three-dimensional extracellular polymeric substance
(EPS), not only function as signaling networks, provide nutritional support, and facilitate …

Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms

P Baker, PJ Hill, BD Snarr, N Alnabelseya… - Science …, 2016 - science.org
Bacterial biofilms present a significant medical challenge because they are recalcitrant to
current therapeutic regimes. A key component of biofilm formation in the opportunistic …

Biofilm dispersal: multiple elaborate strategies for dissemination of bacteria with unique properties

C Guilhen, C Forestier, D Balestrino - Molecular microbiology, 2017 - Wiley Online Library
In most environments, microorganisms evolve in a sessile mode of growth, designated as
biofilm, which is characterized by cells embedded in a self‐produced extracellular matrix …

Matrix exopolysaccharides; the sticky side of biofilm formation

E Maunders, M Welch - FEMS microbiology letters, 2017 - academic.oup.com
Abstract The Gram-negative pathogen Pseudomonas aeruginosa is found ubiquitously
within the environment and is recognised as an opportunistic human pathogen that …

What's on the outside matters: the role of the extracellular polymeric substance of Gram-negative biofilms in evading host immunity and as a target for therapeutic …

JS Gunn, LO Bakaletz, DJ Wozniak - Journal of Biological Chemistry, 2016 - ASBMB
Biofilms are organized multicellular communities encased in an extracellular polymeric
substance (EPS). Biofilm-resident bacteria resist immunity and antimicrobials. The EPS …

Enzymatic dispersion of biofilms: An emerging biocatalytic avenue to combat biofilm-mediated microbial infections

R Ramakrishnan, AK Singh, S Singh… - Journal of Biological …, 2022 - ASBMB
Drug resistance by pathogenic microbes has emerged as a matter of great concern to
mankind. Microorganisms such as bacteria and fungi employ multiple defense mechanisms …

Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems

CR Thorn, PL Howell, DJ Wozniak, CA Prestidge… - Advanced Drug Delivery …, 2021 - Elsevier
Biofilm-dispersing enzymes degrade the extracellular polymeric matrix surrounding bacterial
biofilms, disperse the microbial community and increase their susceptibility to antibiotics and …

Recent insights in microbial exopolysaccharide biosynthesis and engineering strategies

J Schmid - Current opinion in biotechnology, 2018 - Elsevier
Highlights•Wzx proteins show specificity as well as promiscuity for substrate
recognition.•Synthetic biology can enable tailored polysaccharide production.•Single …