Epigenome editing has rapidly evolved in recent years, with diverse applications that
include elucidating gene regulation mechanisms, annotating coding and noncoding …

Transcription factors play an indispensable role in maintaining cellular viability and finely
regulating complex internal metabolic networks. These crucial bioactive functions rely on …

Regardless of the presence or absence of specific diagnostic mutations, many cancer
patients fail to respond to EGFR-targeted therapeutics, and a personalized approach is …

There is an unmet need for functional primary human hepatocytes to support the
pharmaceutical and (bio) medical demand. The unique discovery, a decade ago, that …

With the recent advancements in genome editing, next-generation sequencing (NGS), and
scalable cloning techniques, scientists can now conduct genetic screens at unprecedented …

Single-cell technologies enable the dynamic analyses of cell fate mapping. However,
capturing the gene regulatory relationships and identifying the driver factors that control cell …

Transcription factor over-expression is a proven method for reprogramming cells to a
desired cell type for regenerative medicine and therapeutic discovery. However, a general …

The search for effective therapeutic targets in fields like regenerative medicine and cancer
research has generated interest in cell fate reprogramming. This cellular reprogramming …

Trastuzumab, a HER2-targeted antibody, is widely used for targeted therapy of HER2-
positive breast cancer (BC) patients; yet, not all of them respond to this treatment. We …

Transcription factors (TFs) are essential players in orchestrating the regulatory landscape in
cells. Still, their exact modes of action and dependencies on other regulatory aspects remain …